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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 223 - 227 (5page)
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Purpose: A chemosensitivity test can reflect the differences in responses of individual cancer patients to chemotherapeutic agents. The adenosine triphosphatebasedchemotherapy response assay (ATP-CRA)is an accurate method, which does not require a large amount of tissue specimen. So far, no studies have evaluated the utility of the ATP-CRA in Korea. Therefore, we investigated the clinical usefulness of the ATP-CRA in 53 patients with lung cancer.
Materials and Methods: Tumor tissues were obtained from bronchoscopic biopsies or surgical resections. The validity of ATP-CRA was assessed focusing on the success rate, experimental error level (intraassay mean coefficient of variation [CV]) and reproducibility.
Results: The overall success rate of ATP-CRA was 90.6% (48/53). Normal cells were effectively eliminated from the tumor tissues with the use of ficoll gradient centrifugation and immunomagnetic separation, which was confirmed using loss of heterozygosity analysis of the 3p deletion. The mean CV of ATP assays was 10.5± 4.6%. The reproducibility of ATP assays was 94±3.8%. The results of the ATP assays were reported to physicians within 7 days of specimen collection. More than 6 anticancer drugs were tested on the tumor specimens obtained from bronchoscopic biopsies.
Conclusion: The ATP-CRA is a stable, accurate and potentially practical chemosensitivity test in patients with lung cancer.
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참고문헌 (25)
참고문헌 신청
/ / Annual Report of Death StatisticsData in 2003
/ 1978 / Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs 298 : 1321 ~ 7
/ 1987 / The ATP assayis more sensitive than the succinate dehydrogenase inhibitiontest for predicting cell viability 23 : 273 ~ 6
/ 1989 / Tumor tissue is more sensitive to mitomycin C and aclacinomycin A than is adjacent normal tissue in vitro : 4 ~ 7
/ 1991 / Chemosensitivity testing with highly purifiedfresh human tumour cells with the MTT colorimetric assay 7 : 1258 ~ 63
/ 1978 / Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs 298 : 1321 ~ 7
/ 1987 / The ATP assayis more sensitive than the succinate dehydrogenase inhibitiontest for predicting cell viability 23 : 273 ~ 6
/ 1989 / Tumor tissue is more sensitive to mitomycin C and aclacinomycin A than is adjacent normal tissue in vitro : 4 ~ 7
/ 1991 / Chemosensitivity testing with highly purifiedfresh human tumour cells with the MTT colorimetric assay 7 : 1258 ~ 63
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