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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 970 - 977 (8page)
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Purpose We evaluated the usefulness of the in vitro adenosine triphosphate-based chemotherapy response assay (ATP-CRA) for prediction of clinical response to fluorouracil-based adjuvant chemotherapy in stage II colorectal cancer.
Materials and Methods Tumor specimens of 86 patients with pathologically confirmed stage II colorectal adenocarcinoma were tested for chemosensitivity to fluorouracil. Chemosensitivity was determined by cell death rate (CDR) of drug-exposed cells, calculated by comparing the intracellular ATP level with that of untreated controls.
Results Among the 86 enrolled patients who underwent radical surgery followed by fluorouracilbased adjuvant chemotherapy, recurrence was found in 11 patients (12.7%). The CDR ! 20% group was associated with better disease-free survival than the CDR < 20% group (89.4% vs. 70.1%, p=0.027). Multivariate analysis showed that CDR < 20% and T4 stage were poor prognostic factors for disease-free survival after fluorouracil-based adjuvant chemotherapy.
Conclusion In stage II colorectal cancer, the in vitro ATP-CRA may be useful in identifying patients likely to benefit from fluorouracil-based adjuvant chemotherapy.
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참고문헌 (25)
참고문헌 신청
Hamburger AW / 1977 / Primary bioassay of human tumor stem cells / Science 197:461~463
Rozencweig M / 1984 / In vitro growth of human malignancies in a cloning assay / Recent Results Cancer Res 94:1~7
Yamaue H / 1991 / Chemosensitivity testing with highly purified fresh human tumour cells with the MTT colorimetric assay / Eur J Cancer 27:1258~1263
Vescio RA / 1987 / In vivo-like drug responses of human tumors growing in three-dimensional gel-supported primary culture / Proc Natl Acad Sci U S A 84:5029~5033
Shin Myung Kang / 2005 / A Feasibility Study of Adenosine Triphosphate-based Chemotherapy Response Assay (ATP-CRA) as a Chemosensitivity Test for Lung Cancer / Cancer Research and Treatment 37(4):223~227
Rozencweig M / 1984 / In vitro growth of human malignancies in a cloning assay / Recent Results Cancer Res 94:1~7
Yamaue H / 1991 / Chemosensitivity testing with highly purified fresh human tumour cells with the MTT colorimetric assay / Eur J Cancer 27:1258~1263
Vescio RA / 1987 / In vivo-like drug responses of human tumors growing in three-dimensional gel-supported primary culture / Proc Natl Acad Sci U S A 84:5029~5033
Shin Myung Kang / 2005 / A Feasibility Study of Adenosine Triphosphate-based Chemotherapy Response Assay (ATP-CRA) as a Chemosensitivity Test for Lung Cancer / Cancer Research and Treatment 37(4):223~227
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