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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 827 - 834 (8page)
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Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein expressed in hepatocytes rather than in immune cells affects the CD8+ T cell response. In order to transduce genes selectively into hepatocytes, we developed a baculoviral vector system that enabled primary hepatocytes to express a target epitope for CD8+ T cells, derived from ovalbumin (OVA), with or without HCV core protein. Culture of OVA-specific CD8+ T cells with hepatocytes infected with these baculoviral vectors revealed that core protein has no effect on proliferation or apoptosis of CD8+ T cells. Our results suggest that HCV core protein does not exert its suppressive role on the CD8+ T cell immune response through expression in hepatocytes.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ / In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial : 12221 ~ 7
/ 1995 / Efficient gene transfer into human hepatocytes by baculovirus vectors 92 : 10099 ~ 103
/ 1997 / Yewdell JW Localization quantitation and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody 6 : 715 ~ 26
/ 1998 / Characteristics of virus-specific CD8 T cells in the liver during the control and resolution phases of influenza pneumonia 85 : 13812 ~ 7
/ 1998 / Dynamics of intra-hepatic lymphocytes in chronic hepatitis C enrichment for Vα24+ T cells and rapid elimination of effector cells by apoptosis 28 : 3448 ~ 55
/ 1995 / Efficient gene transfer into human hepatocytes by baculovirus vectors 92 : 10099 ~ 103
/ 1997 / Yewdell JW Localization quantitation and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody 6 : 715 ~ 26
/ 1998 / Characteristics of virus-specific CD8 T cells in the liver during the control and resolution phases of influenza pneumonia 85 : 13812 ~ 7
/ 1998 / Dynamics of intra-hepatic lymphocytes in chronic hepatitis C enrichment for Vα24+ T cells and rapid elimination of effector cells by apoptosis 28 : 3448 ~ 55
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