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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,064 - 1,071 (8page)
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Purpose: To explore the influence of S100 calcium binding protein A4 (S100A4) knockout (KO) on methionine-choline-deficient(MCD) diet-induced non-alcoholic fatty liver disease (NAFLD) in mice. Materials and Methods: S100A4 KO mice (n=20) and their wild-type (WT) counterparts (n=20) were randomly divided into KO/MCD, Ko/methionine-choline-sufficient (MCS), WT/MCD, and WT/MCS groups. After 8 weeks of feeding, blood lipid and liverfunction-related indexes were measured. HE, Oil Red O, and Masson stainings were used to observe the changes of liver histopathology. Additionally, expressions of S100A4 and proinflammatory and profibrogenic cytokines were detected by qRT-PCR andWestern blot, while hepatocyte apoptosis was revealed by TUNEL staining. Results: Serum levels of aminotransferase, aspartate aminotransferase, triglyceride, and total cholesterol in mice were increasedafter 8-week MCD feeding, and hepatocytes performed varying balloon-like changes with increased inflammatory cell infiltrationand collagen fibers; however, these effects were improved in mice of KO/MCD group. Meanwhile, total NAFLD activity scoresand fibrosis were lower compared to WT+MCD group. Compared to WT/MCS group, S100A4 expression in liver tissue of WT/MCD group was enhanced. The expression of proinflammatory (TNF-α, IL-1β, IL-6) and profibrogenic cytokines (TGF-β1, COL1A1,α-SMA) in MCD-induced NAFLD mice were increased, as well as apoptotic index (AI). For MCD group, the expressions ofproinflammatory and profibrogenic cytokines and AI in KO mice were lower than those of WT mice. Conclusion: S100A4 was detected to be upregulated in NAFLD, while S100A4 KO alleviated liver fibrosis and inflammation, inaddition to inhibiting hepatocyte apoptosis.
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참고문헌 (40)
참고문헌 신청
Peter Arner / 2018 / Screening of potential adipokines identifies S100A4 as a marker of pernicious adipose tissue and insulin resistance / International Journal of Obesity 42(12):2047~2056
Afonso MB / 2016 / Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma / J Clin Med 5:30
Nair S / 2002 / Nonalcoholic Fatty liver disease from the perspective of an internist / Ochsner J 4:92~97
Patel A / 2012 / Hepatitis C virus infection and nonalcoholic steatohepatitis / Gastroenterol Hepatol(N Y) 8:305~312
Dongiovanni P / 2016 / Genetics of nonalcoholic fatty liver disease / Metabolism 65:1026~1037
Afonso MB / 2016 / Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma / J Clin Med 5:30
Nair S / 2002 / Nonalcoholic Fatty liver disease from the perspective of an internist / Ochsner J 4:92~97
Patel A / 2012 / Hepatitis C virus infection and nonalcoholic steatohepatitis / Gastroenterol Hepatol(N Y) 8:305~312
Dongiovanni P / 2016 / Genetics of nonalcoholic fatty liver disease / Metabolism 65:1026~1037
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