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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,079 - 1,087 (9page)
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Purpose: Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease(CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however,underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS canlead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the interventioneffects of antioxidant tempol. Materials and Methods: Male Wistar rats (n=66) were exposed to normal oxygen [normal control (NC) group], intermittent hypoxia(IH group), cigarette smoke (CH group), as well as cigarette smoke and IH (OS group). Tempol intervention was assessed inOS group treated with tempol (OST group) or NaCl (OSN group). After an 8-week challenge, lung tissues, serum, and fresh bloodwere harvested for analysis of endothelial markers and apoptosis. Results: The levels of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, and apoptosis in circulating epithelialcells were the highest in OS group and the lowest in NC group. These levels were all greater in IH group than in CH group,and were lower in OST group than in OS and OSN groups (all p<0.001). Conclusion: Synergistic effects of IH with cigarette smoke-induced emphysema produce a greater inflammatory status and endothelialapoptosis. OS-related inflammation and endothelial cell apoptosis may play important roles in promoting cardiovasculardysfunction, and antioxidant tempol could achieve a partial protective effect.
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참고문헌 (40)
참고문헌 신청
Li S / 2016 / Delayed neutrophil apoptosis mediates intermittent hypoxia-induced progressive heart failure in pressure-overloaded rats / Sleep Breath 20:95~102
Turcani P / 2015 / The prevalence of obstructive sleep apnea in patients hospitalized for COPD exacerbation / Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159:422~428
Peppard PE / 2000 / Prospective study of the association between sleep-disordered breathing and hypertension / N Engl J Med 342:1378~1384
Nakanishi K / 2011 / Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice : implications for therapy / Am J Respir Crit Care Med 183:1164~1175
Adeloye D / 2015 / Global and regional estimates of COPD prevalence : systematic review and meta-analysis / J Glob Health 5:020415
Turcani P / 2015 / The prevalence of obstructive sleep apnea in patients hospitalized for COPD exacerbation / Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159:422~428
Peppard PE / 2000 / Prospective study of the association between sleep-disordered breathing and hypertension / N Engl J Med 342:1378~1384
Nakanishi K / 2011 / Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice : implications for therapy / Am J Respir Crit Care Med 183:1164~1175
Adeloye D / 2015 / Global and regional estimates of COPD prevalence : systematic review and meta-analysis / J Glob Health 5:020415
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