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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 838 - 844 (7page)
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초록· 키워드
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Purpose: Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after regional I/R injury and whether ethyl pyruvate protects against delayed regional I/R injury in an in vivo rat heart model after a 24 hours reperfusion. Materials and Methods: Rats were randomized to receive lactated Ringer’s solution or ethyl pyruvate dissolved in Ringer’s solution, which was given by intraperitoneal injection 1 hour prior to ischemia. Rats were subjected to 30 min of ischemia followed by reperfusion of the left coronary artery territory. After a 2 hours reperfusion, nuclear factor κB, myocardial myeloperoxidase activity, and inflammatory cytokine levels were determined. After the 24 hours reperfusion, the hemodynamic function and myocardial infarct size were evaluated. Results: At 2hours after I/R injury, ethyl pyruvate attenuated I/R-induced nuclear factor κB translocation and reduced myeloperoxidase activity in myocardium. The plasma circulating levels of inflammatory cytokines decreased significantly in the ethyl pyruvate-treated group. At 24 hours after I/R injury, ethyl pyruvate significantly improved cardiac function and reduced infarct size after regional I/R injury.
Conclusion: Ethyl pyruvate has the ability to inhibit neutrophil activation,inflammatory cytokine release, and nuclear factor κB translocation. Ethyl pyruvate is associated with a delayed myocardial protective effect after regional I/R injury in an in vivo rat heart model.
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참고문헌 (24)
참고문헌 신청
Barnes PJ / 1997 / Nuclear factor-kappaB; a pivotal transcription factor in chronic inflammatory diseases / N Engl J Med 336 : 1066 ~ 1071
Brand KA / 1997 / Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species / FASEB J 11 : 388 ~ 395
Chandrasekar B / 1997 / Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium / FEBS Lett 401 : 30 ~ 34
Cicalese L / 1996 / Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine / Am J Surg 171 : 97 ~ 100
Dobsak P / 1999 / Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia / J Cardiovasc Pharmacol 34 : 651 ~ 659
Brand KA / 1997 / Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species / FASEB J 11 : 388 ~ 395
Chandrasekar B / 1997 / Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium / FEBS Lett 401 : 30 ~ 34
Cicalese L / 1996 / Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine / Am J Surg 171 : 97 ~ 100
Dobsak P / 1999 / Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia / J Cardiovasc Pharmacol 34 : 651 ~ 659
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