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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.5
- 수록면
- 345 - 350 (6page)
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초록· 키워드
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Purpose: Reactive oxygen species (ROS) significantly contribute to ischemia-reperfusion injury, and are also associated with the gradual loss of renal function and renal failure following renal transplantation. Pyruvate is an endogenous antioxidant, but its use as a therapeutic agent for treating conditions mediated by oxidative stress is limited due to its poor stability in solution. However, ethyl pyruvate (EP), a soluble pyruvate derivative, has far greater stability than pyruvate; thus, may serve as a practical pyruvate precursor. Therefore, the ability of EP in the prevention of renal ischemia- reperfusion injury was assessed.
Methods: Sprague-Dawley rats (n=54) were subjected to 40 minutes of renal warm ischemia. The animals were divided into three groups: the sham group without warm ischemia (n=18), the EP group (n=18, EP given before ischemia), and the ischemic control (n=18). The serum levels of creatinine and TNF-α were measured 1, 3 and 5 days after induction of ischemia. The expression of high mobility group box-1 (HMGB-1), a delayed inflammatory mediator, was also assessed by Western blot of renal specimens.
Results: In the EP group, late improvements in the serum levels of creatinine and TNF-α were observed in comparison with the ischemic control. Based on this delayed effect, the expression of HMGB-1 was assessed in renal tissue. The HMGB-1 expression increased over time during the ischemia process, but EP suppressed this expression 3 and 5 days after renal ischemia-reperfusion injury.
Conclusion: These results have demonstrated, for the first time, that EP ameliorates renal ischemia-reperfusion injury. EP attenuates the renal ischemia-reperfusion injury, at least in part, by suppressing the expression of HMGB-1, a late mediator of delayed inflammation.
Methods: Sprague-Dawley rats (n=54) were subjected to 40 minutes of renal warm ischemia. The animals were divided into three groups: the sham group without warm ischemia (n=18), the EP group (n=18, EP given before ischemia), and the ischemic control (n=18). The serum levels of creatinine and TNF-α were measured 1, 3 and 5 days after induction of ischemia. The expression of high mobility group box-1 (HMGB-1), a delayed inflammatory mediator, was also assessed by Western blot of renal specimens.
Results: In the EP group, late improvements in the serum levels of creatinine and TNF-α were observed in comparison with the ischemic control. Based on this delayed effect, the expression of HMGB-1 was assessed in renal tissue. The HMGB-1 expression increased over time during the ischemia process, but EP suppressed this expression 3 and 5 days after renal ischemia-reperfusion injury.
Conclusion: These results have demonstrated, for the first time, that EP ameliorates renal ischemia-reperfusion injury. EP attenuates the renal ischemia-reperfusion injury, at least in part, by suppressing the expression of HMGB-1, a late mediator of delayed inflammation.
목차
서론
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결과
고찰
결론
REFERENCES
참고문헌 (30)
참고문헌 신청
Azuma H , 1997 , Initial ischemia, reperfusion injury influences late functional and structural changes in the kidney , Transplant Proc 29 : 1528 ~ 1529
Troppmann C , 1995 , Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis , Transplantation 59 : 962 ~ 968
Korthuis RJ , 1993 , Reactive oxygen metabolites, neutrophils, and the pathogenesis of ischemic-tissue, reperfusion , Clin Cardiol 16 : 19 ~ 26
Brand K , 1997 , Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield , J Bioenerg Biomembr 29 : 355 ~ 364
Salahudeen AK , 1991 , Hydrogen peroxide- induced renal injury. A protective role for pyruvate in vitro and in vivo , J Clin Invest 88 : 1886 ~ 1893
Troppmann C , 1995 , Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis , Transplantation 59 : 962 ~ 968
Korthuis RJ , 1993 , Reactive oxygen metabolites, neutrophils, and the pathogenesis of ischemic-tissue, reperfusion , Clin Cardiol 16 : 19 ~ 26
Brand K , 1997 , Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield , J Bioenerg Biomembr 29 : 355 ~ 364
Salahudeen AK , 1991 , Hydrogen peroxide- induced renal injury. A protective role for pyruvate in vitro and in vivo , J Clin Invest 88 : 1886 ~ 1893
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UCI(KEPA) : I410-ECN-0101-2013-514-002673554