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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 567 - 579 (13page)
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초록· 키워드
오류제보하기
With advancements in diagnostic techniques, including molecular and clinical imaging, that directly target cancer cells, oligometastaticprostate cancer (PCa) is being diagnosed in patients who were, in the past, considered to have localized disease. Withaccumulating evidence, there has been a paradigm shift in considering aggressive treatments targeted at both the primary tumorand metastatic lesions in an aim to avoid and delay the need for palliative treatments and, ultimately, to achieve survival benefits. However, many questions still remain unanswered regarding the understanding of oligometastatic PCa, from its definition to optimaltreatment strategies for each individual. Limited retrospective studies have suggested that interventions, including localand/or metastasis-directed therapy using surgery and radiation therapy (RT), can improve survival outcomes with minimal riskof adverse effects. Such treatments have been shown to decrease the risks of subsequent palliative interventions and to delay thestart of androgen-deprivation therapy. Nevertheless, available data are insufficient to draw a reliable conclusion regarding theireffect on quality of life measures and overall survival. This comprehensive review overviews data from contemporary literaturethat have investigated treatments, including surgery and RT, for patients with oligometastatic PCa, namely pelvic lymph nodepositive disease and limited distant metastases, and summarizes ongoing trials that are evaluating the feasibility of aggressivemultimodal treatments.
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등록된 정보가 없습니다.
참고문헌 (97)
참고문헌 신청
Hellman S / 1995 / Oligometastases / J Clin Oncol 13:8~10
Uppal A / 2014 / Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs / Clin Exp Metastasis 31:735~748
Haffner MC / 2013 / Tracking the clonal origin of lethal prostate cancer / J Clin Invest 123:4918~4922
James ND / 2016 / Failure-free survival and radiotherapy in patients with newly diagnosed nonmetastatic prostate cancer: data from patients in the control arm of the STAMPEDE Trial / JAMA Oncol 2:348~357
Tward JD / 2013 / Radiation therapy for clinically node-positive prostate adenocarcinoma is correlated with improved overall and prostate cancer-specific survival / Pract Radiat Oncol 3:234~240
Uppal A / 2014 / Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs / Clin Exp Metastasis 31:735~748
Haffner MC / 2013 / Tracking the clonal origin of lethal prostate cancer / J Clin Invest 123:4918~4922
James ND / 2016 / Failure-free survival and radiotherapy in patients with newly diagnosed nonmetastatic prostate cancer: data from patients in the control arm of the STAMPEDE Trial / JAMA Oncol 2:348~357
Tward JD / 2013 / Radiation therapy for clinically node-positive prostate adenocarcinoma is correlated with improved overall and prostate cancer-specific survival / Pract Radiat Oncol 3:234~240
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