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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,266 - 1,273 (8page)
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초록· 키워드
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Purpose: This study examined the clinical effectiveness of parenteral cefuroxime and cefotaxime as empirical antibiotics for treating hospitalized women with uncomplicated acute pyelonephritis (APN).
Materials and Methods: This study was based on the clinical and microbiologic data of 255 hospitalized women with APN. Of these 255 women, 144 patients received cefuroxime and 111 received cefotaxime.
Results: There were no marked differences in the demographic features, clinical characteristics, and treatment duration between the populations of the cefuroxime and cefotaxime groups. The rates of defervescence showed no significant differences in the two groups at 48, 72, 96, and 120 hours. The clinical cure rates observed at the follow-up visit 4 to 14 days after the completion of antimicrobialtherapy were not statistically different between the cefuroxime and cefotaxime groups [94.9% (129 of 136) versus 98.0% (100 of 102), respectively; p=0.307], and the microbiological cure rates were also not significantly different [88.3% (91 of 103) versus 95.0% (76 of 80), respectively; p=0.186]. The median hospitalization periods in the cefuroxime and cefotaxime groups were 7 (6–8) and 7 (6–8) days (p=0.157), respectively. Microbiological success rates after 72–96 hours of initial antimicrobial therapy were also not statistically different in the cefuroxime and cefotaxime groups, 89.4% (110 of 123) versus 94.9% (93 of 98; p=0.140).
Conclusion: Cefuroxime, a second-generation cephalosporin, is an appropriate antibiotic option for the initial treatment of uncomplicatedAPN and its efficacy does not differ from cefotaxime, a third-generation cephalosporin, in the initial parenteral therapyfor community-onset APN.
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참고문헌 (20)
참고문헌 신청
Clinical and Laboratory Standard Institute / 2005 / Performance standards for antimicrobial susceptibility testing: 15th informational supplement: approved standard MI00-S15 / Clinica
Gupta K / 2011 / International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Dis
Jones RN / 1977 / Cefuroxime, a new parenteral cephalosporin: collaborative in vitro susceptibility comparison with cephalothin against 5,887 clinical bacterial isolates / An
Leigh DA / 1989 / Treatment of acute uncomplicated urinary tract infections with single daily doses of cefuroxime axetil / J Antimicrob Chemother 23 : 267 ~ 273
Naber KG / 2002 / Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated
Gupta K / 2011 / International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Dis
Jones RN / 1977 / Cefuroxime, a new parenteral cephalosporin: collaborative in vitro susceptibility comparison with cephalothin against 5,887 clinical bacterial isolates / An
Leigh DA / 1989 / Treatment of acute uncomplicated urinary tract infections with single daily doses of cefuroxime axetil / J Antimicrob Chemother 23 : 267 ~ 273
Naber KG / 2002 / Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated
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