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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 961 - 967 (7page)
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Purpose: Low serum concentrations of drugs used to treat multi-drug resistant tuberculosis(MDR-TB) have occasionally been associated with treatment failure. We determined the frequencies of low serum concentrations of anti-MDR-TB drugs, and assessed the effects of these concentrations on 2-month sputum conversion. Materials and Methods: The serum levels of moxifloxacin (MF), prothionamide (PTH), and cycloserine (CS) were determined for 89 serum samples by high-pressureliquid chromatography-tandem mass spectrometry. Results: Low serum concentrationsof MF, PTH, and CS below the minimal levels of the normal ranges were 83.3% (20/24), 59.2% (29/49), and 71.2% (47/66), respectively. There were no significant differences between the 2-month sputum conversion group (n=25) and the 2-month sputum non-conversion group (n=4) in median drug concentrations(μg/mL) of MF (1.46 vs. 1.60), PTH (0.91 vs. 0.70), and CS (14.90 vs. 14.90). However, a poor compliance rate was significantly greater in the 2-month sputum non-conversion group (75.0%, 3/4) than in the 2-month sputum conversion group (0%, 0/25) (p=0.001). Conclusion: The frequency of low serum concentrations of anti-MDR-TB drugs was substantial and might not affect the 2-month sputum conversionrate. Larger prospective studies with timely sampling are needed to investigatethe role of therapeutic drug monitoring in MDR-TB.
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참고문헌 (23)
참고문헌 신청
Alffenaar JW / 2009 / Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis / Clin Infect Dis 49 : 1080 ~ 1082
Bai GH / 2007 / Trend of anti-tuberculosis drug resistance in Korea, 1994-2004 / Int J Tuberc Lung Dis 11 : 571 ~ 576
Blumberg HM / 2003 / American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America : treatment of tuberculosis / Am J Respir Cri
Cremades R / 2011 / Comparison of the bactericidal activity of various fluoroquinolones against Mycobacterium tuberculosis in an in vitro experimental model / J Antimicrob Ch
Gler MT / 2012 / Vargas-Vasquez DE, et al. Delamanid for multidrug-resistant pulmonary tuberculosis / N Engl J Med 366 : 2151 ~ 2160
Bai GH / 2007 / Trend of anti-tuberculosis drug resistance in Korea, 1994-2004 / Int J Tuberc Lung Dis 11 : 571 ~ 576
Blumberg HM / 2003 / American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America : treatment of tuberculosis / Am J Respir Cri
Cremades R / 2011 / Comparison of the bactericidal activity of various fluoroquinolones against Mycobacterium tuberculosis in an in vitro experimental model / J Antimicrob Ch
Gler MT / 2012 / Vargas-Vasquez DE, et al. Delamanid for multidrug-resistant pulmonary tuberculosis / N Engl J Med 366 : 2151 ~ 2160
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