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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 760 - 771 (12page)
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초록· 키워드
오류제보하기
Purpose: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention of osteoporosis through the maintenance of reactive oxygenspecies (ROS) at a favorable level. Materials and Methods: In this study, a novel antioxidant, namely 3,4,5-Trihydroxy-N-[4-(5-hydroxy-6-methoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-benzamide (ZXHA-TC) was synthesized from gallic acid and sulfadimoxine. Its effect on osteoblast metabolism was investigated via the detection of cell proliferation, cell viability, production of ROS, and expression of osteogenic-specific genes including runt-related transcription factor 2 (RUNX2), bone sialoprotein (BSP), osteocalcin (OCN), alpha-1 type I collagen (COL1A1), and osteogenic-related proteins after treatment for 2, 4, and 6 days respectively. Results: The results showed that ZXHA-TC has a stimulating effect on the proliferation and osteogenic differentiation of primary osteoblasts by promoting cell proliferation, cell viability, and the expression of genes BSP and OCN. Productions of bone matrix and mineralization were also increased by ZXHA-TC treatment as a result of up-regulationof COL1A1 and alkaline phosphatase (ALP) at the early stage and down-regulationof both genes subsequently. A range of 6.25×10-3 μg/mL to 6.25×10-1 μg/mL is the recommended dose for ZXHA-TC, within which 6.25×10-2 μg/mL showed the best performance. Conclusion: This study may hold promise for the development of a novel agent for the treatment of osteoporosis.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Andersen SJ / 2007 / Osteoporosis in the older woman / Clin Obstet Gynecol 50 : 752 ~ 766
Arjmandi BH / 1996 / Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis / J Nutr 126 : 161 ~ 167
Chuang CY / 2010 / Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway / J Agric F
Gold DT / 2006 / Osteoporosis and depression: a historical perspective / Curr Osteoporos Rep 4 : 134 ~ 139
Ho HH / 2010 / Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition
Arjmandi BH / 1996 / Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis / J Nutr 126 : 161 ~ 167
Chuang CY / 2010 / Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway / J Agric F
Gold DT / 2006 / Osteoporosis and depression: a historical perspective / Curr Osteoporos Rep 4 : 134 ~ 139
Ho HH / 2010 / Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition
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