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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 405 - 408 (4page)
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초록· 키워드
오류제보하기
Purpose: The in vitro study suggested that proline to serine polymorphism in codon 475 (C1423T) of the A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats-13 (ADAMTS-13) gene is related to reduced activity of ADAMTS- 13. In this study, the frequency of the Pro475Ser polymorphism in Koreans was studied and plasma ADAMTS-13 activity was measured to find out whether this polymorphism contributes to decreased ADAMTS-13 activity in Koreans. Patients and Methods: The frequency of the C1423T allele of the ADAMTS13 gene was studied along with measuring plasma ADAMTS-13 activity in 250 healthy Korean individuals. Results: The allele frequency of C1423T polymorphism was 4%, and the median activity of CT type was 107 (69-143)%, which was lower than in controls with the CC genotype [118 (48-197)%, (p=0.021)]. Conclusion: Therefore, the Pro475Ser polymorphism seems to be popular in the Korean population, and attenuates ADAMTS-13 plasma activity.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Bianchi V / 2002 / Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopeni
Bongers TN / 2005 / Absence of Pro475Ser polymorphism in ADAMTS-13 in Caucasians / J Thromb Haemost 3 : 805 ~
Dong JF / 2003 / ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor / J Biol Chem 278 : 29633 ~ 29639
Fujikawa K / 2001 / Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family / Blood 98 : 1662 ~ 1
Gerritsen HE / 2001 / Partial amino acid sequence of purified von Willebrand factor-cleaving protease / Blood 98 : 1654 ~ 1661
Bongers TN / 2005 / Absence of Pro475Ser polymorphism in ADAMTS-13 in Caucasians / J Thromb Haemost 3 : 805 ~
Dong JF / 2003 / ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor / J Biol Chem 278 : 29633 ~ 29639
Fujikawa K / 2001 / Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family / Blood 98 : 1662 ~ 1
Gerritsen HE / 2001 / Partial amino acid sequence of purified von Willebrand factor-cleaving protease / Blood 98 : 1654 ~ 1661
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