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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 93 - 98 (6page)
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초록· 키워드
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Biosynthetic processing of fibrillar procollagens is essential for producing mature collagen monomers that polymerize into fibrils by a self-assembly process. The metalloproteinase ADAMTS-2 is the major enzyme that processes the N-propeptide of type I procollagen in the skin and also of type II and type III procollagens. Mutations in the ADAMTS-2 gene cause dermatospraxis in animals and Ehlers-Danlos syndrome VIIC in humans, both of which are characterized by the accumulation of type I pN-collagen and the formation of abnormal collagen fibrils in the skin. Despite its importance in procollagen processing, little is known about the regulation of ADAMTS-2 expression. Here, we demonstrate that ADAMTS-2 can be regulated by 1,25-dihydroxyvitamin D3, an inducer of type I procollagen synthesis. This steroid hormone induced ADAMTS-2 mRNA ~3-fold in MG-63 human osteosarcoma cells and MC3T3-E1 murine osteoblastic cells. This induction was dose- and time-dependent in MG-63 cells. In contrast, secreted ADAMTS-2 protein was increased only 1.4-fold with 1,25-dihydroxyvitamin D3. Finally, 1,25-dihydroxyvitamin D3 in the presence of ascorbate increased levels of secreted ADAMTS-2 1.9-fold over ascorbate treatment alone, which did not appreciably change ADAMTS-2 expression. These data indicate that the regulation of ADAMTS-2 is coupled with the synthesis of type I procollagen through 1,25-dihydroxyvitamin D3 signaling and may involve translational or posttranslational control.
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참고문헌 (25)
참고문헌 신청
/ 1985 / 1 alpha, 25-dihydroxy-vitamin D3 specific regulation of growth, morphology, and fibronectin in a human osteosarcoma cell line 123 : 401 ~ 409
/ 1986 / 1,25-Dihydroxy-vitamin D3 and human bone-derived cells in vitro: effects on alkaline phosphatase, type I collagen and proliferation endocri (logy) : 1776 ~ 1785
/ 1986 / Effects of 1 25-dihydroxyvitamin D3 on osteoblastic MC3T3-E1 cells endocri (logy) : 940 ~ 947
/ 1987 / Regulation of cellular adhesion and fibronectin synthesis by 1 alpha : 25 4165 ~ 4171
/ 1987 / Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta
/ 1986 / 1,25-Dihydroxy-vitamin D3 and human bone-derived cells in vitro: effects on alkaline phosphatase, type I collagen and proliferation endocri (logy) : 1776 ~ 1785
/ 1986 / Effects of 1 25-dihydroxyvitamin D3 on osteoblastic MC3T3-E1 cells endocri (logy) : 940 ~ 947
/ 1987 / Regulation of cellular adhesion and fibronectin synthesis by 1 alpha : 25 4165 ~ 4171
/ 1987 / Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta
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