지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 501 - 510 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients,Western populations, or use of an outdated imaging technique. We investigated the characteristics of AIs in Korean patients andcompared them with those reported in the largest retrospective study in Italy to discover the effects of improved imaging techniquesand ethnicity differences. Materials and Methods: This was a prospective, multicenter, cross-sectional observational study including 1005 Korean patients. Levels of plasma adrenocorticotrophic hormone, 24-h urinary free cortisol (UFC), serum cortisol after a 1 mg-dexamethasonesuppression test, 24-h urinary fractionated metanephrine, and plasma aldosterone and plasma renin activity were measured. AllAIs were characterized using computed tomography (CT). Results: Compared with the results of the Italian study, AIs in Korean patients were observed more frequently in men and predominantlyon the left side. Korean patients with AIs were slightly younger, and fewer patients underwent surgery. Most AIs werenonfunctional in both studies, while fewer subclinical hypercortisolism and more primary aldosteronism (PA) cases were detectedin Korean patients. In our study, high UFC levels showed very low sensitivity, compared to those in the Italian study. In pheochromocytomaor PA cases, there were no hormonal differences between the studies. AIs in Korean patients were smaller, suchthat a lower cutoff size for detecting adrenocortical carcinoma (ACC) could be warranted. Conclusion: Recent advances in CT technology were leveraged to provide accurate characteristics of AIs and to detect smallerACCs.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Kloos RT / 1995 / Incidentally discovered adrenal masses / Endocr Rev 16:460~484
Terzolo M / 2011 / AME position statement on adrenal incidentaloma / Eur J Endocrinol 164:851~870
Arnaldi G / 2012 / Adrenal incidentaloma / Best Pract Res Clin Endocrinol Metab 26:405~419
Ambrosi B / 1995 / Abnormalities of endocrine function in patients with clinically silent adrenal masses / Eur J Endocrinol 132:422~428
Androulakis II / 2011 / The clinical significance of adrenal incidentalomas / Eur J Clin Invest 41:552~560
Terzolo M / 2011 / AME position statement on adrenal incidentaloma / Eur J Endocrinol 164:851~870
Arnaldi G / 2012 / Adrenal incidentaloma / Best Pract Res Clin Endocrinol Metab 26:405~419
Ambrosi B / 1995 / Abnormalities of endocrine function in patients with clinically silent adrenal masses / Eur J Endocrinol 132:422~428
Androulakis II / 2011 / The clinical significance of adrenal incidentalomas / Eur J Clin Invest 41:552~560
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