지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 9 - 17 (9page)
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초록· 키워드
오류제보하기
Intrinsic cellular defenses are non-specific antiviral activities by recognizing pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs), one of the pathogen recognize receptor (PRR), sense various microbial ligands. Especially, TLR2, TLR3, TLR4, TLR7, TLR8 and TLR9 recognize viral ligands such as glycoprotein,single- or double-stranded RNA and CpG nucleotides. The binding of viral ligands to TLRs transmits its signal to Toll/interleukin-1 receptor (TIR) to activate transcription factors via signal transduction pathway. Through activation of transcription factors, such as interferon regulatory factor-3, 5, and 7 (IRF-3, 5, 7) or nuclear factor- κB (NF-κB), type I interferons are induced, and antiviral proteins such as myxovirus-resistance protein (Mx) GTPase,RNA-dependent Protein Kinase (PKR), ribonuclease L (RNase L), Oligo-adenylate Synthetase (OAS) and Interferon Stimulated Gene (ISG) are further expressed. These antiviral proteins play an important role of antiviral resistancy against several viral pathogens in infected cells and further activate innate immune responses.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alexopoulou L / 2001 / Recognition of double-stranded RNA and activation of NF-kappaB by Tolllike receptor 3 / Nature 413 : 732 ~ 738
Andreakos E / 2004 / Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of
Awomoyi AA / 2007 / Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in highrisk infants and young children / J Immunol 179 : 3171 ~ 3
Bell JK / 2006 / The dsRNA binding site of human Toll-like receptor 3 / Proc Natl Acad Sci U S A 103 : 8792 ~ 8797
Bogdan C / 2000 / The function of type I interferons in antimicrobial immunity / Curr Opin Immunol 1 : 419 ~ 424
Andreakos E / 2004 / Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of
Awomoyi AA / 2007 / Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in highrisk infants and young children / J Immunol 179 : 3171 ~ 3
Bell JK / 2006 / The dsRNA binding site of human Toll-like receptor 3 / Proc Natl Acad Sci U S A 103 : 8792 ~ 8797
Bogdan C / 2000 / The function of type I interferons in antimicrobial immunity / Curr Opin Immunol 1 : 419 ~ 424
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