지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 784 - 788 (5page)
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초록· 키워드
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Purpose: We identified pediatric liver transplant recipients with successful withdrawal of immunosuppression who
developed tolerance in Korea. Materials and Methods: Among 105 pediatric patients who received liver
transplantation and were treated with tacrolimus-based immunosuppressive regimens, we selected five (4.8%)
patients who had very low tacrolimus trough levels. Four of them were noncompliant with their medication and one
was weaned off of immunosuppression due to life threatening posttransplant lymphoproliferative disorder. We
reviewed the medical records with regard to the relationship of the donor-recipients, patient characteristics and
prognosis, including liver histology, and compared our data with previous reports. Results: Four patients received
the liver transplantation from a parent donor and one patient from a cadaver donor. A trial of withdrawal of the
immunosuppressant was started a median of 45 months after transplantation (range, 14 months to 60 months), and
the period of follow up after weaning from the immunosuppressant was a median of 32 months (range, 14 months
to 82 months). None of the five patients had rejection episodes after withdrawal of the immunosuppression; they
maintained normal graft function for longer than 3 years (median, 38 months; range, 4 to 53 months). The
histological findings of two grafts 64 and 32 months after weaning-off of the medication showed no evidence of
chronic rejection. Conclusion: The favorable markers for successful withdrawal of immunosuppression were 1)
long-term (> 3 years) stable graft function, 2) no rejection for longer than 1 year after withdrawal of immunosuppression,
3) non-immune mediated liver diseases, and 4) pediatric patients.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Devlin J / 1998 / Defining the outcome of immunosuppression withdrawal after liver transplantation / Hepatology 27 : 926 ~ 933
Eason JD / 2005 / Tolerance: is it worth the risk? / Transplantation 79 : 1157 ~ 1159
Hurwitz M / 2004 / Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation / Pediatr Tra
Koshiba T / 2007 / Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation / Transpl Immunol 17 : 94 ~
Lerut J / 2006 / An appraisal of tolerance in liver transplantation / Am J Transplant 6 : 1774 ~ 1780
Eason JD / 2005 / Tolerance: is it worth the risk? / Transplantation 79 : 1157 ~ 1159
Hurwitz M / 2004 / Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation / Pediatr Tra
Koshiba T / 2007 / Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation / Transpl Immunol 17 : 94 ~
Lerut J / 2006 / An appraisal of tolerance in liver transplantation / Am J Transplant 6 : 1774 ~ 1780
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