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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제16권 제4호
- 발행연도
- 2013.1
- 수록면
- 207 - 218 (12page)
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초록· 키워드
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Long term outcomes after liver transplantation are major determinants of quality of life and of the value of this heroic treatment. As short term outcomes are excellent, our community is turning to take a harder look at long term outcomes. The purpose of this paper is to review these outcomes, and highlight proposed treatments, as well as pressing topics needing to be studied. A systemic review of the English literature was carried in PubMed, covering all papers address-ing long term outcomes in pediatric liver transplant from 2000-2013. Late outcomes after pediatric liver transplant affect the liver graft in the form of chronic liver dysfunction. The causes include rejection particularly humoral rejection, but also de novo autoimmune hepatitis, and recurrent disease. The metabolic syndrome is a major factor in long term cardiovascular complication risk. Secondary infections, kidney dysfunction and malignancy remain a reality of those patients. There is growing evidence of late cognitive and executive function delays affecting daily life pro-ductivity as well as likely adherence. Finally, despite a good health status, quality of life measures are comparable to those of children with chronic diseases. Long term outcomes are the new frontier in pediatric liver transplantation. Much is needed to improve graft survival, but also to avoid systemic morbidities from long term immunosuppression. Quality of life is a new inclusive measure that will require interventions and innovative approaches respectful not only on the patients but also of their social circle.
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참고문헌 (22)
참고문헌 신청
Aguilera I / 2011 / Complement component 4d immunostaining in liver allografts of patients with de novo immune hepatitis / Liver Transpl 17 : 779 ~ 788
Bekker J / 2009 / Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risk factors / Am J Transplant 9 : 746 ~ 757
Campbell K / 2010 / SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience / Am J Transplant 10 : 267
Centers for Disease Control and Prevention (CDC) / 2013 / Advisory Committee on Immunization Practices (ACIP) recommended immunization schedule for persons aged 0 through 18
Codoner-Franch P / 1994 / Long-term follow-up of growth in height after successful liver transplantation / J Pediatr 124 : 368 ~ 373
Bekker J / 2009 / Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risk factors / Am J Transplant 9 : 746 ~ 757
Campbell K / 2010 / SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience / Am J Transplant 10 : 267
Centers for Disease Control and Prevention (CDC) / 2013 / Advisory Committee on Immunization Practices (ACIP) recommended immunization schedule for persons aged 0 through 18
Codoner-Franch P / 1994 / Long-term follow-up of growth in height after successful liver transplantation / J Pediatr 124 : 368 ~ 373
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