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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 22 - 30 (9page)
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초록· 키워드
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Chitin, the second most abundant polysaccharide in nature after cellulose, consist exoskeleton of lower organisms such as fungi, crustaceans and insects except mammals. Recently, several studies evaluated immunologic effects of chitin in vivo and in vitro and revealed new aspects of chitin regulation of innate and adaptive immune responses. It has been shown that exogenous chitin activates macrophages and other innate immune cells and also modulates adaptive type 2 allergic inflammation. These studies further demonstrate that chitin stimulate macrophages by interacting with different cell surface receptors such as macrophage mannose receptor, toll-like receptor 2 (TLR-2), C-type lectin receptor Dectin-1, and leukotriene B4 recepptor (BLT1). On the other hand, a number of chitinase or chitinase-like proteins (C/CLP) are ubiquitously expressed in the airways and intestinal tracts from insects to mammals. In general, these chitinase family proteins confer protective functions to the host against exogenous chitin-containing pathogens. However, substantial body of recent studies also set light on new roles of C/CLP in the development and progression of allergic inflammation and tissue remodeling. In this review, recent findings on the role of chitin and C/CLP in allergic inflammation and tissue remodeling will be highlighted and controversial and unsolved issues in this field of studies will be discussed.
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참고문헌 (67)
참고문헌 신청
Shibata Y / 1997 / Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice / Infect Immun 65:1734~1741
Bourbouze R / 1991 / N-acetyl-beta-D-glucosaminidase (NAG) isoenzymes release from human monocyte-derived macrophages in response to zymosan and human recombinant interferon-gamma / Clin Chim Acta 199:185~194
Reese TA / 2007 / Chitin induces accumulation in tissue of innate immune cells associated with allergy / Nature 447:92~96
Zhang Y / 2006 / Cross-reactivity among shrimp, crab and scallops in a patient with a seafood allergy / J Dermatol 33:174~177
Desjardins A / 1995 / Occupational IgE-mediated sensitization and asthma caused by clam and shrimp / J Allergy Clin Immunol 96:608~617
Bourbouze R / 1991 / N-acetyl-beta-D-glucosaminidase (NAG) isoenzymes release from human monocyte-derived macrophages in response to zymosan and human recombinant interferon-gamma / Clin Chim Acta 199:185~194
Reese TA / 2007 / Chitin induces accumulation in tissue of innate immune cells associated with allergy / Nature 447:92~96
Zhang Y / 2006 / Cross-reactivity among shrimp, crab and scallops in a patient with a seafood allergy / J Dermatol 33:174~177
Desjardins A / 1995 / Occupational IgE-mediated sensitization and asthma caused by clam and shrimp / J Allergy Clin Immunol 96:608~617
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