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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제50권 제1호
발행연도
2009.1
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39 - 44 (6page)

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Purpose: To evaluate the merit of umbilical artery Doppler study as a predictive marker of perinatal outcome in preterm small for gestational age (SGA) infants. Materials and Methods: A total of 218 patients at 27-36 weeks of gestational age (GA) who received antenatal umbilical artery Doppler velocimetry and delivered singleton infants with SGA. The ratio of peak-systolic to end-diastolic blood flow velocities (S/D) in the umbilical artery was measured in each patient. The patients were divided into 3 groups: the normal group with S/D ratios of less than 95th percentile (n=134), elevated S/D ratio group of 95th or more percentile (n=41), and those with absent/reversed end diastolic flow (n=43). Maternal characteristics and neonatal outcomes of these groups were comparatively analyzed. Results: The gestational age (GA) at the time of diagnosis of SGA, the mean GA at delivery, and the mean birth weight showed statistically significant difference among three groups (p<0.001). Also, poor perinatal outcome was significantly increased in infants with abnormal S/D ratio (13.4% vs. 31.7% vs. 67.4%, p<0.001). Multivariate logistic regression analysis revealed umbilical artery Doppler study as a significant independent factor for prediction of poor perinatal outcome (odds ratio: 3.7, 95% confidence interval 1.4-9.5, p=0.007). Conclusion: Antenatal umbilical artery Doppler velocimetry is shown as a significantly efficient marker in predicting perinatal outcome in preterm SGA infants.

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