지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 839 - 844 (6page)
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초록· 키워드
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Purpose: We hypothesized that parenteral nutrition associated cholestasis (PNAC) would be more severe in small for gestational age (SGA) compared with appropriate for gestational age (AGA) very low birth weight (VLBW) infants. Materials and Methods: Sixty-one VLBW infants were diagnosed as PNAC with exposure to parenteral nutrition with elevation of direct bilirubin ≥2 mg/dL for ≥14 days. Twenty-one SGA infants and 40 AGA infants matched for gestation were compared.
Results: Compared with AGA infants, PNAC in SGA infants was diagnosed earlier (25±7 days vs. 35±14 days, p=0.002) and persisted longer (62±36 days vs. 46±27 days, p=0.048). Severe PNAC, defined as persistent elevation of direct bilirubin ≥4 mg/dL for more than 1 month with elevation of liver enzymes, was more frequent in SGA than in AGA infants (61% vs. 35%, p=0.018). The serum total bilirubin and direct bilirubin levels during the 13 weeks of life were significantly different in SGA compared with AGA infants. SGA infants had more frequent (76% vs. 50%, p=0.046), and persistent elevation of alanine aminotransferase.
Conclusion: The clinical course of PNAC is more persistent and severe in SGA infants. Careful monitoring and treatment are required for SGA infants.
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참고문헌 (23)
참고문헌 신청
Aucott SW / 2004 / Increased morbidity in severe early intrauterine growth restriction / J Perinatol 24 : 435 ~ 440
Baserga MC / 2004 / Intrauterine growth restriction impacts tolerance to total parenteral nutrition in extremely low birth weight infants / J Perinatol 24 : 476 ~ 481
Beale EF / 1979 / Intrahepatic cholestasis associated with parenteral nutrition in premature infants / Pediatrics 64 : 342 ~ 347
Beath SV / 1996 / Parenteral nutrition-related cholestasis in postsurgical neonates: multivariate analysis of risk factors / J Pediatr Surg 31 : 604 ~ 606
Bernstein IM / 2000 / Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network / Am J Obstet Gynecol 182
Baserga MC / 2004 / Intrauterine growth restriction impacts tolerance to total parenteral nutrition in extremely low birth weight infants / J Perinatol 24 : 476 ~ 481
Beale EF / 1979 / Intrahepatic cholestasis associated with parenteral nutrition in premature infants / Pediatrics 64 : 342 ~ 347
Beath SV / 1996 / Parenteral nutrition-related cholestasis in postsurgical neonates: multivariate analysis of risk factors / J Pediatr Surg 31 : 604 ~ 606
Bernstein IM / 2000 / Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network / Am J Obstet Gynecol 182
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