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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,286 - 1,289 (4page)
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The causes of cytopenia in patients with severe fever with thrombocytopenia syndrome (SFTS) are not fully understood until now. We reviewed the bone marrow (BM) findings of patients with SFTS to unravel the cause of the cytopenia. Three Korean SFTS were enrolled in this study. Thrombocytopenia, neutropenia, and anemia were detected in all three patients. Severe hypocellular marrow(overall cellularity <5%) and a decreased number of megakaryocytes were noted in one patient, and hypo-/normocellular marrow and an increased number of hemophagocytic histiocytes were observed in two patients. Megakaryocytes were relatively preserved in two patients. Although a limited number of cases are available, our observations suggest that both BM suppression and peripheral destruction or sequestration are causes of cytopenia of patients with SFTS. To the best of our knowledge, this is the first well documented pathologic evaluation of Korean SFTS.
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참고문헌 (12)
참고문헌 신청
Yu XJ / 2011 / Fever with thrombocytopenia associated with a novel bunyavirus in China / N Engl J Med 364:1523~1532
QuanTai X / 2013 / A study of cytological changes in the bone marrow of patients with severe fever with thrombocytopenia syndrome / PLoS One 8:e83020
Takahashi T / 2014 / The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan / J Infect Dis 209:816~827
Jin C / 2012 / Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model / Proc Natl Acad Sci U S A 109:10053~10058
Kim WY / 2015 / Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea / Clin Infect Dis 60:1681~1683
QuanTai X / 2013 / A study of cytological changes in the bone marrow of patients with severe fever with thrombocytopenia syndrome / PLoS One 8:e83020
Takahashi T / 2014 / The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan / J Infect Dis 209:816~827
Jin C / 2012 / Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model / Proc Natl Acad Sci U S A 109:10053~10058
Kim WY / 2015 / Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea / Clin Infect Dis 60:1681~1683
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