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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 621 - 625 (5page)
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초록· 키워드
오류제보하기
Purpose: To compare the effectiveness of device closure and medical therapy in prevention of recurrent embolic event in the Koreanpopulation with cryptogenic stroke and patent foramen ovale (PFO).
Materials and Methods: Consecutive 164 patients (men: 126 patients, mean age: 48.1 years, closure group: 72 patients, medical group: 92 patients) were enrolled. The primary end point was a composite of death, stroke, transient ischemic attack (TIA), or peripheralembolism.
Results: Baseline characteristics were similar in the two groups, except age, which was higher in the medical group (45.3±9.8 vs. 50.2±6.1, p<0.0001), and risk of paradoxical embolism score, which was higher in the closure group (6.2±1.6 vs. 5.7±1.3, p=0.026). On echocardiography, large right-to-left shunt (81.9% vs. 63.0%, p=0.009) and shunt at rest/septal hypermobility (61.1% vs. 23.9%, p<0.0001) were more common in the closure group. The device was successfully implanted in 71 (98.6%) patients. The primary end point occurred in 2 patients (2 TIA, 2.8%) in the closure group and in 2 (1 death, 1 stroke, 2.2%) in the medical group. Event-free survival rate did not differ between the two groups.
Conclusion: Compared to medical therapy, device closure of PFO in patients with cryptogenic stroke did not show difference in reduction of recurrent embolic events in the real world’s setting. However, considering high risk of echocardiographic findings in the closure group, further investigation of the role of PFO closure in the Asian population is needed.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Lechat P / 1988 / Prevalence of patent foramen ovale in patients with stroke / N Engl J Med 318:1148~1152
Furlan AJ / 2012 / Closure or medical therapy for cryptogenic stroke with patent foramen ovale / N Engl J Med 366:991~999
Meier B / 2013 / Percutaneous closure of patent foramen ovale in cryptogenic embolism / N Engl J Med 368:1083~1091
Carroll JD / 2013 / Closure of patent foramen ovale versus medical therapy after cryptogenic stroke / N Engl J Med 368:1092~1100
Agarwal S / 2012 / Metaanalysis of transcatheter closure versus medical therapy for patent foramen ovale in prevention of recurrent neurological events after presumed paradoxical embolism / JACC Cardiovasc Interv 5:777~789
Furlan AJ / 2012 / Closure or medical therapy for cryptogenic stroke with patent foramen ovale / N Engl J Med 366:991~999
Meier B / 2013 / Percutaneous closure of patent foramen ovale in cryptogenic embolism / N Engl J Med 368:1083~1091
Carroll JD / 2013 / Closure of patent foramen ovale versus medical therapy after cryptogenic stroke / N Engl J Med 368:1092~1100
Agarwal S / 2012 / Metaanalysis of transcatheter closure versus medical therapy for patent foramen ovale in prevention of recurrent neurological events after presumed paradoxical embolism / JACC Cardiovasc Interv 5:777~789
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