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Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This paper reviews the current understanding of the pathophysiology of stroke and therapeutic options in patients with PFO and ESUS.
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참고문헌 (24)
참고문헌 신청
Abushora MY / 2013 / Intrapulmonary shunt is a potentially unrecognized cause of ischemic stroke and transient ischemic attack / J Am Soc Echocardiogr 26 : 683 ~ 690
Alsheikh-Ali AA / 2009 / Patent foramen ovale in cryptogenic stroke: incidental or pathogenic? / Stroke 40 : 2349 ~ 2355
Anzola GP / 2003 / Transcranial Doppler and risk of recurrence in patients with stroke and patent foramen ovale / Eur J Neurol 10 : 129 ~ 135
Bang
Bhatia N / 2014 / Determination of the optimum number of cardiac cycles to differentiate intra-pulmonary shunt and patent foramen ovale by saline contrast two- and three-dim
Alsheikh-Ali AA / 2009 / Patent foramen ovale in cryptogenic stroke: incidental or pathogenic? / Stroke 40 : 2349 ~ 2355
Anzola GP / 2003 / Transcranial Doppler and risk of recurrence in patients with stroke and patent foramen ovale / Eur J Neurol 10 : 129 ~ 135
Bang
Bhatia N / 2014 / Determination of the optimum number of cardiac cycles to differentiate intra-pulmonary shunt and patent foramen ovale by saline contrast two- and three-dim
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