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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 652 - 657 (6page)
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Purpose: Acute hepatitis A (AHA) and acute hepatitis B (AHB) are caused by an acute infection of the hepatitis A virus and the hepatitis B virus, respectively. In both AHA and AHB, liver injury is known to be mediated by immune cells and cytokines. In this study, we measured serum levels of various cytokines and T-cell cytotoxic proteins in patients with AHA or AHB to identify liver injury-associated cytokines.
Materials and Methods: Forty-six patients with AHA, 16 patients with AHB, and 14 healthy adults were enrolled in the study. Serumlevels of 17 cytokines and T-cell cytotoxic proteins were measured by enzyme-linked immunosorbent assays or cytometric bead arrays and analyzed for correlation with serum alanine aminotransferase (ALT) levels.
Results: Interleukin (IL)-18, IL-8, CXCL9, and CXCL10 were significantly elevated in both AHA and AHB. IL-6, IL-22, granzyme B, and soluble Fas ligand (sFasL) were elevated in AHA but not in AHB. In both AHA and AHB, the serum level of CXCL10 significantlycorrelated with the peak ALT level. Additionally, the serum level of granzyme B in AHA and the serum level of sFasL in AHB correlated with the peak ALT level.
Conclusion: We identified cytokines and T-cell cytotoxic proteins associated with liver injury in AHA and AHB. These findings deepen the existing understanding of immunological mechanisms responsible for liver injury in acute viral hepatitis.
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참고문헌 (34)
참고문헌 신청
정성준 / 2014 / Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea / Clinical and Molecular Hepatology 20(2):162~167
Wasley A / 2006 / Hepatitis A in the era of vaccination / Epidemiol Rev 28:101~111
Franco E / 2012 / Hepatitis A:epidemiology and prevention in developing countries / World J Hepatol 4:68~73
Collier MG / 2015 / Hepatitis A hospitalizations in the United States, 2002-2011 / Hepatology 61:481~485
Koff RS / 1998 / Hepatitis A / Lancet 351:1643~1649
Wasley A / 2006 / Hepatitis A in the era of vaccination / Epidemiol Rev 28:101~111
Franco E / 2012 / Hepatitis A:epidemiology and prevention in developing countries / World J Hepatol 4:68~73
Collier MG / 2015 / Hepatitis A hospitalizations in the United States, 2002-2011 / Hepatology 61:481~485
Koff RS / 1998 / Hepatitis A / Lancet 351:1643~1649
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