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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제23권 제2호
- 발행연도
- 2020.1
- 수록면
- 180 - 187 (8page)
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초록· 키워드
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Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell transformation of hepatocytes. Here, we report a case involving a seven-month-old male infant who presented with AHA followed by cholestatic hepatitis. The clinical features included jaundice, pallor, and red urine. Physical examination showed generalized icterus and splenomegaly. The laboratory findings suggested warm-type AHA with cholestatic hepatitis. Liver biopsy revealed giant cell transformation of hepatocytes and moderate lobular inflammation. The patient was successfully treated with four doses of rituximab. Early relapse of hemolytic anemia and hepatitis was observed, which prompted the use of an additional salvage dose of rituximab. He is currently in clinical remission.
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참고문헌 (25)
참고문헌 신청
Bernard O / 1981 / Severe giant cell hepatitis with autoimmune hemolytic anemia in early childhood / J Pediatr 99:704~711
Whitington PF / 2014 / Humoral immune mechanism of liver injury in giant cell hepatitis with autoimmune hemolytic anemia / J Pediatr Gastroenterol Nutr 58:74~80
Maggiore G / 2011 / Giant cell hepatitis with autoimmune hemolytic anemia in early childhood : long-term outcome in 16 children / J Pediatr 159:127~132
Gorelik M / 2004 / Autoimmune hemolytic anemia with giant cell hepatitis : case report and review of the literature / J Pediatr Hematol Oncol 26:837~839
Cho MH / 2016 / Giant cell hepatitis with autoimmune hemolytic anemia in a Korean infant / Pediatr Int 58:628~631
Whitington PF / 2014 / Humoral immune mechanism of liver injury in giant cell hepatitis with autoimmune hemolytic anemia / J Pediatr Gastroenterol Nutr 58:74~80
Maggiore G / 2011 / Giant cell hepatitis with autoimmune hemolytic anemia in early childhood : long-term outcome in 16 children / J Pediatr 159:127~132
Gorelik M / 2004 / Autoimmune hemolytic anemia with giant cell hepatitis : case report and review of the literature / J Pediatr Hematol Oncol 26:837~839
Cho MH / 2016 / Giant cell hepatitis with autoimmune hemolytic anemia in a Korean infant / Pediatr Int 58:628~631
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