Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A

Hyosun Cho; Hyojeung Kang; Chang Wook Kim; Hee Yeon Kim; Jeong Won Jang; 윤승규; 이창돈

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자료유형: 학술저널

저자정보: Hyosun Cho Hyojeung Kang Chang Wook Kim Hee Yeon Kim Jeong Won Jang 윤승규 이창돈

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제10권 제2호

발행연도: 2016.1

수록면: 288 - 294 (7page)

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Background/Aims: The immunoregulatory molecules programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are associated with the dysfunction of antiviral effector T-cells, which leads to T-cell exhaustion and persistent viral infection in patients with chronic hepatitis C and chronic hepatitis B. Little is known about the role of PD-1 and CTLA-4 in patients with symptomatic acute hepatitis A (AHA). Methods: Peripheral blood mononuclear cells were isolated from seven patients with AHA and from six patients with nonviral acute toxic hepatitis (ATH) during the symptomatic and convalescent phases of the respective diseases; five healthy subjects acted as controls. The expression of PD-1 and CTLA-4 on T-cells was measured by flow cytometry. Results: PD-1 and CTLA-4 expression during the symptomatic phase was significantly higher in the Tcells of AHA patients than in those of ATH patients or healthy controls (PD-1: 18.3% vs 3.7% vs 1.6%, respectively, p<0.05; CTLA-4: 23.5% vs 6.1% vs 5.9%, respectively, p<0.05). The levels of both molecules decreased dramatically during the convalescent phase of AHA, whereas a similar pattern was not seen in ATH. Conclusions: Our findings are consistent with a viral-protective effect of PD-1 and CTLA-4 as inhibitory molecules that suppress cytotoxic T-cells and thereby prevent the destruction of virus-infected hepatocytes in AHA.

#Acute hepatitis A #Cytotoxic T lymphocyte-associated antigen 4 #Programmed death 1

참고문헌 (15)

참고문헌 신청

De Filippis P / 1987 / Detection of hepatitis A virus in the stools of healthy people from endemic areas / Eur J Epidemiol 3:172~175

Kwon SY / 2009 / Current status of liver diseases in Korea: hepatitis A / Korean J Hepatol 15(6):S7~S12

Fife BT / 2008 / Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways / Immunol Rev 224:166~182

Nakamoto N / 2009 / Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade / PLoS Pathog 5:e1000313

Evans A / 2008 / Programmed death 1 expression during antiviral treatment of chronic hepatitis B: impact of hepatitis B e-antigen seroconversion / Hepatology 48:759~769

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