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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 679 - 686 (8page)
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The objectives of this study were to explore whether ovarian vascular endothelial growth factor (VEGF) expression in mice can be regulated by IL-6 (interleukin-6), angiotensin II, FSH, and hCG; and to test whether the mouse ovarian VEGF expression can result in angiogenesis. The ICR mice were sacrificed, and their ovaries were recovered. Recovered ovaries were treated with IL-6, angiotensin II, FSH, and hCG separately and incubated for 24 hours in α-MEM. Expression of mRNA and protein of VEGF were assessed by RT-PCR and immunohistochemistry. The resulting angiogenesis was evaluated through immunohistochemical analysis for CD34. Treatment of mice ovaries with IL-6, FSH, and hCG resulted in a significant increase of VEGF mRNA, and IL-6 was the most potent inducer of VEGF. IL-6 and FSH resulted in increased neovascularization in the follicular phase of mouse ovaries. In contrast, angiotensin II could not increase VEGF expression or neovascularization. We documented an in vitro increase in VEGF expression by IL-6, FSH, and hCG; and reaffirmed that the proliferative response of murine ovarian endothelial cells paralleled an increase of VEGF expression.
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참고문헌 (25)
참고문헌 신청
/ / Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis : 3092 ~ 6
/ 1947-51 / relationship to follicular size
/ 1995 / Angiotensin II increases vascular permeability factor gene expression by human vascular smooth muscle cells 25 : 913 ~ 7
/ 1996 / Angiogenesis in the ovary 1 : 182 ~ 92
/ 1996 / Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtype 137 : 1204 ~ 11
/ 1947-51 / relationship to follicular size
/ 1995 / Angiotensin II increases vascular permeability factor gene expression by human vascular smooth muscle cells 25 : 913 ~ 7
/ 1996 / Angiogenesis in the ovary 1 : 182 ~ 92
/ 1996 / Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtype 137 : 1204 ~ 11
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