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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 353 - 358 (6page)
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The aim of this study was to assess the involvement of multipotential progenitor cells in the pathogenesis of Mooren's ulcer using immunohistochemical staining techniques. Tissue specimens were collected from 3 Mooren's ulcer patients who underwent lamellar keratectomy. Immunohistochemical staining patterns were analyzed using antibodies: CD34, c-kit, STRO-1, CD45RO, VEGF and α-SMA. Strong positive CD34, c-kit and STRO-1 cells were revealed in Mooren's ulcer specimens, especially in the superficial stroma. A few weakly expressed CD34 stroma cells were seen in normal limbal cornea but no immunoreactivity for c-kit and STRO-1 could be found. CD45RO positive T cells were found to have infiltrated in Mooren's ulcer. The immunostaining pattern of VEGF and α- SMA was closely correlated with the degree of expression and the number of CD34 positive cells. Bone marrow-derived multipotential progenitor cells may be involved in the pathogenesis of Mooren's ulcer by synergizing with other factors to amplify autoimmune destructive reactions and to contribute to the regeneration process. Specific therapeutic strategies that target the role of these cells in the disease are warranted.
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참고문헌 (33)
참고문헌 신청
[학술지(정기간행
/ / A monoclonal antibody against α- smooth muscle differentiation : 2787 ~ 96
/ / Corneal autoimmunity in patients with peripheral ulcerative keratitis in association with rheumatoid arthritis and Wegener's granulomatosis : 630 ~ 6
/ / Identification of stroma cell precursors in human bone marrow by a novel monoclonal antibody : 55 ~ 1 62
/ / Immunologic disorders of the cornea and conjunctiva
/ / A monoclonal antibody against α- smooth muscle differentiation : 2787 ~ 96
/ / Corneal autoimmunity in patients with peripheral ulcerative keratitis in association with rheumatoid arthritis and Wegener's granulomatosis : 630 ~ 6
/ / Identification of stroma cell precursors in human bone marrow by a novel monoclonal antibody : 55 ~ 1 62
/ / Immunologic disorders of the cornea and conjunctiva
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