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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 107 - 113 (7page)
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Purpose: Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurologic morbidity in infants and children. We investigated the effects of pentoxifylline, a methylxanthine derivative and type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal cell death in the hippocampus following perinatal hypoxic-ischemia in newborn rats.
Methods: We used a step-down avoidance task to evaluate short-term memory and 3ʹ-5ʹ-cyclic adenosine monophosphate (cAMP) assay to detect cAMP levels. We evaluated apoptosis using a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for evidence of DNA fragmentation, immunohistochemistry for caspase-3 levels, and western blot for Bcl-2 and Bax.
Results: Perinatal hypoxic-ischemic injury increased apoptotic cell death in the hippocampus, resulting in impaired shortterm memory with decreased cAMP levels. Pentoxifylline treatment improved short-term memory by suppressing apoptotic cell death in the hippocampus with elevated cAMP levels.
Conclusions: Pentoxifylline ameliorated perinatal hypoxic-ischemia in rat pups. This alleviating effect could be ascribed to the inhibition apoptosis due to increased cAMP production by pentoxifylline.
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참고문헌 (32)
참고문헌 신청
Ferriero DM / 2004 / Neonatal brain injury / N Engl J Med 351:1985~1995
Ness JM / 2006 / Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia / Brain Res 1099:150~159
Cho YS / 2015 / Ulinastatin inhibits cerebral ischemia-induced apoptosis in the hippocampus of gerbils / Mol Med Rep 12:1796~1802
최준호 / 2013 / Short-term treadmill exercise preserves sensory-motor function through inhibiting apoptosis in the hippocampus of hypoxic ischemia injury rat pups / Journal of exercise rehabilitation 9(5):457~462
Ko IG / 2009 / Tadalafil improves short-term memory by suppressing ischemiainduced apoptosis of hippocampal neuronal cells in gerbils / Pharmacol Biochem Behav 91:629~635
Ness JM / 2006 / Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia / Brain Res 1099:150~159
Cho YS / 2015 / Ulinastatin inhibits cerebral ischemia-induced apoptosis in the hippocampus of gerbils / Mol Med Rep 12:1796~1802
최준호 / 2013 / Short-term treadmill exercise preserves sensory-motor function through inhibiting apoptosis in the hippocampus of hypoxic ischemia injury rat pups / Journal of exercise rehabilitation 9(5):457~462
Ko IG / 2009 / Tadalafil improves short-term memory by suppressing ischemiainduced apoptosis of hippocampal neuronal cells in gerbils / Pharmacol Biochem Behav 91:629~635
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