지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 258 - 265 (8page)
- DOI
- 10.5125/jkaoms.2020.46.4.258
이용수
초록· 키워드
오류제보하기
Objectives: Despite advances in maxillofacial surgery, impaired bone healing remains a concern for surgical teams. Many studies have evaluated the effects of sildenafil and pentoxifylline on bone healing. However, their effects on healing of bone fractures have not been well investigated. This study aimed to assess the effects of the phosphodiesterase inhibitors sildenafil and pentoxifylline on healing of mandibular fractures in rats. Materials and Methods: A total of 60 rats were randomly divided into six groups of 10. Mandibular fracture was induced in all rats. After the surgi-cal procedure, group C1 received saline, group S1 received 10 mg/kg sildenafil and group P1 received 50 mg/kg pentoxifylline. The rats were sacri-ficed after 1 week. Groups C4, S4, and P4 received pharmaceutical therapy as in groups C1, S1, and P1 but were sacrificed after 4 weeks. The samples then underwent histological analysis. Results: The mean rate of bone healing of mandibular fractures in groups S1 and P1 was significantly higher than in group C1 at 1 week (P<0.001). The mean rate of bone healing of mandibular fractures in group P1 was higher than in group S1 at 1 week (P=0.04). The mean rate of bone healing of mandibular fractures in groups S4 (P=0.001) and P4 (P=0.004) was significantly higher than in group C4 at 4 weeks, but no significant difference was noted in the rate of healing between groups P4 and S4 (P=0.53).Conclusion: Sildenafil and pentoxifylline can be used as adjuncts to enhance bone healing in rats.
목차
등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Glória JCR / 2018 / Comparison of bite force with locking plates versus non-locking plates in the treatment of mandibular fractures : a meta-analysis / Int Arch Otorhinolaryngol 22:181~189
Uçan MC / 2013 / Influence of caffeic acid phenethyl ester on bone healing in a rat model / J Int Med Res 41:1648~1654
Fernández JR / 2003 / A threedimensional numerical simulation of mandible fracture reduction with screwed miniplates / J Biomech 36:329~337
Durmuş K / 2017 / Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: an experimental study / Adv Clin Exp Med 26:1063~1067
Hausman MR / 2001 / Prevention of fracture healing in rats by an inhibitor of angiogenesis / Bone 29:560~564
Uçan MC / 2013 / Influence of caffeic acid phenethyl ester on bone healing in a rat model / J Int Med Res 41:1648~1654
Fernández JR / 2003 / A threedimensional numerical simulation of mandible fracture reduction with screwed miniplates / J Biomech 36:329~337
Durmuş K / 2017 / Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: an experimental study / Adv Clin Exp Med 26:1063~1067
Hausman MR / 2001 / Prevention of fracture healing in rats by an inhibitor of angiogenesis / Bone 29:560~564
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