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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 339 - 344 (6page)
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초록· 키워드
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Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome is unclear. Here we report the case of a 36-year-old woman who presented with pain in multiple bones and proteinuria. She had a 7-year history of taking adefovir at 10 mg/day for chronic hepatitis B. Three years previously she had received surgery for a nontraumatic right femur neck fracture, after which she continued to complain of pain in multiple bones, and proteinuria, glycosuria, and phosphaturia were noted. The findings of a light-microscope examination of a renal biopsy sample were normal, but mitochondrial damage of the proximal tubules was evident in electron microscopy. Western blot analysis revealed that the level of serum fibroblast growth factor 23 (FGF23) was lower than in normal controls. After 2 months of treatment, hypophosphatemia and proximal tubular dysfunction were reversed, and serum FGF23 had normalized. This case suggests that direct mitochondrial damage in proximal tubules can cause drug-induced Fanconi syndrome associated with osteomalacia.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Kahn J / 1999 / Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial / JAMA 282:2305~2312
Hadziyannis SJ / 2003 / Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B / N Engl J Med 348:800~807
정영걸 / 2010 / Fanconi’s Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient / Gut and Liver 4(3):389~393
Girgis CM / 2011 / Hypophosphataemic osteomalacia in patients on adefovir dipivoxil / J Clin gastroenterol 45:468~473
Laing CM / 2005 / Renal tubular acidosis: developments in our understanding of the molecular basis / Int J Biochem Cell Biol 37:1151~1161
Hadziyannis SJ / 2003 / Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B / N Engl J Med 348:800~807
정영걸 / 2010 / Fanconi’s Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient / Gut and Liver 4(3):389~393
Girgis CM / 2011 / Hypophosphataemic osteomalacia in patients on adefovir dipivoxil / J Clin gastroenterol 45:468~473
Laing CM / 2005 / Renal tubular acidosis: developments in our understanding of the molecular basis / Int J Biochem Cell Biol 37:1151~1161
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