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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Adefovir dipivoxil (ADV) and tenofovir disoproxil fumarate (TDF) are nucleotide analogues used to treat chronic hepatitis B (CHB) infection. Nephrotoxicity associated with the use of these medications causes Fanconi syndrome, a rare condition involving generalized dysfunction of the proximal renal tubule causing impaired reabsorption of glucose, uric acid, and phosphate. Fanconi syndrome has been previously reported in patients with human immunodeficiency virus (HIV) or HIV-CHB coinfection treated with other antiretroviral therapies. However, it is rarely reported in patients with CHB monoinfection. We observed a case of Fanconi syndrome in a 61-year-old woman with CHB monoinfection and a history of long-term ADV therapy (42 months), followed by TDF treatment for 9 months. She presented with ankle pain and a tingling sensation in both lower extremities. Laboratory tests revealed hypokalemia, hypocalcemia, hypophosphatemia, hypouricemia, proteinuria, and glycosuria. This case illustrates the importance of recognizing Fanconi syndrome associated with nucleotide analogue treatment and the need to carefully observe symptoms and monitor renal function in these patients. (Korean J Med 2016;91:174-178)
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참고문헌 (10)
참고문헌 신청
Gara N / 2012 / Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B / Aliment Pharmacol Ther 35:1317~1325
정영걸 / 2010 / Fanconi’s Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient / Gut and Liver 4(3):389~393
Kahn J / 1999 / Efficacy and safety of adefovir dipivoxil with antiretroviral therapy : a randomized controlled trial / JAMA 282:2305~2312
Hadziyannis SJ / 2006 / Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years / Gastroenterology 131:1743~1751
Fernandez-Fernandez B / 2011 / Tenofovir nephrotoxicity : 2011 update / AIDS Res Treat 2011:354908
정영걸 / 2010 / Fanconi’s Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient / Gut and Liver 4(3):389~393
Kahn J / 1999 / Efficacy and safety of adefovir dipivoxil with antiretroviral therapy : a randomized controlled trial / JAMA 282:2305~2312
Hadziyannis SJ / 2006 / Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years / Gastroenterology 131:1743~1751
Fernandez-Fernandez B / 2011 / Tenofovir nephrotoxicity : 2011 update / AIDS Res Treat 2011:354908
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