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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 66 - 73 (8page)
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초록· 키워드
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Background/Aims: A recent study reported that entecavir had inferior efficacy in nucleos(t)ide analogue (NA)-experienced chronic hepatitis B (CHB) patients compared to NA-naïve patients. We sought to compare the efficacy of tenofovir disoproxil fumarate (TDF) in NA-experienced and NA-naïve CHB patients.
Methods: We retrospectively enrolled 252 consecutive patients who had a serum hepatitis B virus (HBV) DNA level greater than 2,000 IU/mL at the initiation of TDF treatment and who received TDF for at least 6 months. Complete virologic suppression (CVS) was defined as undetectable serum HBV DNA. We generated a multivariate Cox proportional-hazard model to examine predictive factors that were independently associated with time to CVS.
Results: The mean age of patients was 48.2 years, and the cohort included 181 NA-naïve patients and 71 NA-experienced patients. The median duration of TDF treatment was 14.4 (interquartile range, 9.5-17.8) months. A total of 167 (92.3%) of 181 NA-naïve patients achieved CVS, and 60 (84.5%) of 71 NA-exposed patients achieved CVS. Forty-nine (89.1%) of 55 patients who previously took an NA aside from adefovir and 11 (68.8%) of 16 adefovir-experienced patients achieved CVS. In multivariable analysis, previous adefovir exposure significantly influenced time to CVS (hazard ratio, 0.37; 95% confidence interval, 0.19-0.72; P=0.003), after adjusting for HBeAg positivity, baseline HBV DNA level and cirrhosis.
Conclusions: Tenofovir had inferior efficacy in adefovir-experienced CHB patients compared to NA-naïve patients. The response of patients with previous adefovir exposure to TDF monotherapy should be monitored closely.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Baran B / 2013 / Efficacy of tenofovir in patients with Lamivudine failure is not different from that in nucleoside/nucleotide analogue-naive patients with chronic hepatitis
Chen CF / 2011 / Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma / Gastroenterology 141 : 1240 ~ 1248
Cho EJ / 2015 / Comparison of the efficacy of entecavir and tenofovir in nucleos(t)ide analogue-experienced chronic hepatitis B patients / PLoS One 10 : e0130392 ~
Delaney WE 4th / 2006 / Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus / Antimicrob Agents Chemother 50 : 2471 ~ 2477
European Association For The Study Of The Liver / 2012 / EASL clinical practice guidelines: Management of chronic hepatitis B virus infection / J Hepatol 57 : 167 ~ 185
Chen CF / 2011 / Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma / Gastroenterology 141 : 1240 ~ 1248
Cho EJ / 2015 / Comparison of the efficacy of entecavir and tenofovir in nucleos(t)ide analogue-experienced chronic hepatitis B patients / PLoS One 10 : e0130392 ~
Delaney WE 4th / 2006 / Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus / Antimicrob Agents Chemother 50 : 2471 ~ 2477
European Association For The Study Of The Liver / 2012 / EASL clinical practice guidelines: Management of chronic hepatitis B virus infection / J Hepatol 57 : 167 ~ 185
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