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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 155 - 162 (8page)
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Background/Aims: Because hepatitis B virus (HBV) replication has been known to play an important role in cancer recurrence after curative treatment of HBV-related hepatocellular carcinoma (HCC), we examined whether treatment based on nucleos(t)ide analogues (NAs) might decrease the recurrence rate and improve patient survival.
Methods: The retrospective cohort study enrolled 73 patients with chronic hepatitis B who were treated with transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) with curative intent for HCC. Among those, 30 and 43 patients were treated with tenofovir disoproxil fumarate (TDF) and entecavir (ETV), respectively.
Results: Of the 73 patients, 51 experienced HCC recurrence, and 14 patients were dead during a follow-up of 73±34 months. Multivariate analyses showed that tumor size (hazard ratio [HR], 1.590; 95% confidence-interval [CI], 1.106-2.285; P=0.012) and Child-Pugh class B (vs. class A/non cirrhosis; HR, 5.794; 95% CI, 2.311-14.523; P=0.001) was significantly associated with HCC recurrence, and Child-Pugh class B (HR, 7.357; 95% CI, 2.100-25.777; P=0.002) was an independent unfavorable prognostic factor for survival. During NAs therapy, TDF was superior to ETV for complete viral response at 1 year after the date of combination of TACE and RFA (P=0.016). However, the risks of HCC recurrence and survival were not significantly different between those treated with TDF versus ETV.
Conclusions: TDF was superior to ETV for achieving complete viral response. However, the recurrence and mortality after TACE and RFA for HBV-related HCC were not significantly different between patients treated with TDF versus ETV.
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참고문헌 (25)
참고문헌 신청
Lilian Yan Liang / 2019 / Unmet need in chronic hepatitis B management / Clinical and Molecular Hepatology 25(2):172~180
Schweitzer A / 2015 / Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013 / Lancet 386:1546~1555
Kim BK / 2008 / Persistent hepatitis B viral replication affects recurrence of hepatocellular carcinoma after curative resection / Liver Int 28:393~401
Wu CY / 2012 / Association between nucleoside analogues and risk of hepatitis B virusrelated hepatocellular carcinoma recurrence following liver resection / JAMA 308:1906~1914
Yin J / 2013 / Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus-related hepatocellular carcinoma : a two-stage longitudinal clinical study / J Clin Oncol 31:3647~3655
Schweitzer A / 2015 / Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013 / Lancet 386:1546~1555
Kim BK / 2008 / Persistent hepatitis B viral replication affects recurrence of hepatocellular carcinoma after curative resection / Liver Int 28:393~401
Wu CY / 2012 / Association between nucleoside analogues and risk of hepatitis B virusrelated hepatocellular carcinoma recurrence following liver resection / JAMA 308:1906~1914
Yin J / 2013 / Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus-related hepatocellular carcinoma : a two-stage longitudinal clinical study / J Clin Oncol 31:3647~3655
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