지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 32 - 41 (10page)
이용수
초록· 키워드
오류제보하기
Purpose:Glomerulonephropathy (GN) often manifests as proteinuria and progresses to chronic renal failure without specific therapy. Mesenchymal stem cell (MSC) has been tried as a therapeutic agent in experimental GN, and previous studies showed that administration of MSC concomitantly to the insult inducing GN or via intra-renal administration ameliorated proteinuria. The purpose of this study was to test the therapeutic potential of MSC administered via intravenous route at the time of clinically evident proteinuria.
Methods:MSCs were administered intravenously via tail vain into the mice with adriamycin (ADR) induced nephropathy (ADR-GN), two weeks after ADR injection when massive proteinuria was evident. To test the capacity of MSC modulate the cytokine production in the inflammatory milieu, the concentrations of IFN-γ and IL-10 were measured in the supernatant of in vitro mixed lymphocyte culture (MLC) with or without additional MSC.
Results:MSCs administered intravenously into the proteinuric mice with ADR-GN accelerated the recovery of this experimental GN with disappearance of proteinuria in two weeks when the saline treated (control) mice still showed significant proteinuria. The mice treated with MSC also had a tendency of better survival. Addition of MSC decreased IFN-γ and increased IL-10 in the supernatant of MLC.
Discussion:This study showed that MSC had a therapeutic potential even when administered in a more clinically relevant setting into a proteinuric glomerulonephropathy model. Further study to verify the mechanism and long-term safety of this phenomenon is required.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aggarwal S / 2005 / Human mesenchymal stem cells modulate allogeneic immune cell responses / Blood 105 : 1815 ~ 1822
Barbash IM / 2003 / Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: Feasibility, cell migration, and body distribution / Circulat
Beyth S / 2005 / Human mesenchymal stem cells alter antigen-presenting cell maturation and induce t-cell unresponsiveness / Blood 105 : 2214 ~ 2219
Degauque N / 2008 / Immunostimulatory tim-1-specific antibody deprograms tregs and prevents transplant tolerance in mice / J Clin Invest 118 : 735 ~ 741
Eddy AA / 1989 / Interstitial nephritis induced by protein-overload proteinuria / Am J Pathol 135 : 719 ~ 733
Barbash IM / 2003 / Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: Feasibility, cell migration, and body distribution / Circulat
Beyth S / 2005 / Human mesenchymal stem cells alter antigen-presenting cell maturation and induce t-cell unresponsiveness / Blood 105 : 2214 ~ 2219
Degauque N / 2008 / Immunostimulatory tim-1-specific antibody deprograms tregs and prevents transplant tolerance in mice / J Clin Invest 118 : 735 ~ 741
Eddy AA / 1989 / Interstitial nephritis induced by protein-overload proteinuria / Am J Pathol 135 : 719 ~ 733
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulatory Dendritic Cells Induced by Mesenchymal Stem Cells Ameliorate Dextran Sodium Sulfate-Induced Chronic Colitis in Mice
Gut and Liver
2018 .01
-
Mesenchymal Stem Cells Ameliorate Renal Inflammation in Adriamycin-induced Nephropathy
Immune Network
2019 .10
-
Isolation and characterization of deer-derived mesenchymal stem cells
예방수의학회지
2019 .01
-
Therapeutic potentials occurring during the early differentiation process of mesenchymal stem cells in a rats model with thioacetamide - induced liver fibrosis
Annals of Hepato-Biliary-Pancreatic Surgery
2013 .03
-
비과 영역에서 중간엽줄기세포의 적용
대한이비인후-두경부외과학회지
2014 .01
-
The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema
Tuberculosis and Respiratory Diseases
2015 .01
-
Mesenchymal Stem Cell Lines Isolated by Different Isolation Methods Show Variations in the Regulation of Graft-versus-host Disease
Immune Network
2013 .08
-
임상적용을 위한 세포치료제로서의 성체 중간엽줄기세포
영남의대학술지
2009 .01
-
Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4+CD25+ FoxP3+ Regulatory T-Cells and Induced by TGF-β1 and IL-10
Yonsei Medical Journal
2017 .01
-
Growth Inhibitory Effect of Palatine Tonsil-derived Mesenchymal Stem Cells on Head and Neck Squamous Cell Carcinoma Cells
Clinical and Experimental Otorhinolaryngology
2012 .01
-
The Therapeutic Effect of Human Embryonic Stem Cell-Derived Multipotent Mesenchymal Stem Cells on Chemical-Induced Cystitis in Rats
International Neurourology Journal
2018 .01
-
The effects of h9MSCs transplantation in MI nude mouse model
한국실험동물학회 학술발표대회 논문집
2013 .02
-
Characteristics of mesenchymal stem cells derived from different tissues of goat
예방수의학회지
2019 .01
-
H9MSCs improved cardiac function in mouse model of myocardial infarction
한국실험동물학회 학술발표대회 논문집
2013 .08
-
Immunomodulatory Effects of Mesenchymal Stem Cells in a Murine Model of TNBS-Induced Colitis
Annals of Surgical Treatment and Research
2010 .11
-
Differentiation Potential of Mesenchymal Stem Cells Is Related to Their Intrinsic Mechanical Properties
International Neurourology Journal
2017 .01
-
Tracking Intravenous Adipose-Derived Mesenchymal Stem Cells in a Model of Elastase-Induced Emphysema
Tuberculosis and Respiratory Diseases
2014 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0