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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 96 - 105 (10page)
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초록· 키워드
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Mesenchymal stem cells (MSCs) ameliorate the renal injury in Adriamycin (ADR)-induced nephropathy, but the mechanisms underlying their efficacy remain incompletely understood. In this study, we demonstrated that MSCs increased the survival, recovered body weight loss, and decreased proteinuria and serum creatinine levels in ADR-treated mice. MSCs also prevented podocyte damage and renal fibrosis by decreasing the expression of fibronectin, collagen 1α1, and α-smooth muscle actin. From a mechanistic perspective, MSCs inhibited renal inflammation by lowering the expression of CCL4, CCL7, CCL19, IFN-α/β, TGF-β, TNF-α, and chitinase 3-like 1. In summary, our data demonstrate that MSCs improve renal functions by inhibiting renal inflammation in ADR-induced nephropathy.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
Lee VW / 2011 / Adriamycin nephropathy: a model of focal segmental glomerulosclerosis / Nephrology (Carlton) 16:30~38
Nogueira A / 2017 / Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies / In Vivo 31:1~22
Zhang H / 2017 / AF1q contributes to Adriamycin-induced podocyte injury by activating Wnt/β-catenin signaling / Kidney Blood Press Res 42:794~803
Zoja C / 2012 / Mesenchymal stem cell therapy promotes renal repair by limiting glomerular podocyte and progenitor cell dysfunction in Adriamycin-induced nephropathy / Am J Physiol Renal Physiol 303:F1370~F1381
Huuskes BM / 2015 / Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy / FASEB J 29:540~553
Nogueira A / 2017 / Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies / In Vivo 31:1~22
Zhang H / 2017 / AF1q contributes to Adriamycin-induced podocyte injury by activating Wnt/β-catenin signaling / Kidney Blood Press Res 42:794~803
Zoja C / 2012 / Mesenchymal stem cell therapy promotes renal repair by limiting glomerular podocyte and progenitor cell dysfunction in Adriamycin-induced nephropathy / Am J Physiol Renal Physiol 303:F1370~F1381
Huuskes BM / 2015 / Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy / FASEB J 29:540~553
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UCI(KEPA) : I410-ECN-0101-2019-517-001281748