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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 182 - 187 (6page)
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Zerumbone is a major component of the essential oils of Zingiber zerumbet Smith and is known to have a number of effects on the functions of various cells, including immune cells. Many reports present the zerumbone's functions in various biological environments including cancer and inflammation. In this report, using a transwell system, we confirmed that zerumbone decreased the stromal cell-driven factor-1 (SDF-1), induced migration of Jurkat cells; about a 25% decrease in the case of 100 ng/mL SDF-1 treatment, 17% decrease in the case of 200 ng/mL. Whereas, no significant changes of basic cellular proliferation were observed after zerumbone treatment. These results are novel and promising functions of zerumbone on T cell physiology. At the same time, there is a great need to confirm the results using more physiological T cells and to proceed with cellular and biochemical mechanism studies, measuring apoptosis, CXCR4 expression and phosphorylation of ZAP-70 and Erk1/2.
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참고문헌 (19)
참고문헌 신청
Abdelwahab SI / 2011 / Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells / Leuk Res 35 (2) : 268 ~ 271
Alampour-Rajabi S / 2015 / MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis / Faseb J 29 (11) : 4497 ~ 451
Bordon Y / 2011 / Lymphocyte migration: Travel agents for two / Nat Rev Immunol 11 (2) : 77 ~ 88
Eguchi A / 2007 / Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells / Biosci Biotechnol Biochem 71 (4)
Keong YS / 2010 / Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet / Pak J Pharm Sci 23 (1) : 75 ~ 82
Alampour-Rajabi S / 2015 / MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis / Faseb J 29 (11) : 4497 ~ 451
Bordon Y / 2011 / Lymphocyte migration: Travel agents for two / Nat Rev Immunol 11 (2) : 77 ~ 88
Eguchi A / 2007 / Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells / Biosci Biotechnol Biochem 71 (4)
Keong YS / 2010 / Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet / Pak J Pharm Sci 23 (1) : 75 ~ 82
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