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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 391 - 398 (8page)
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Mesenchymal stem cells (MSCs) are an attractive resource for refractory patients because of their anti-inflammatory/immunomodulatory capability and multi-lineage differentiation potential. The transplantation of MSCs has led to positive results in preclinical and clinical application to various diseases, including autoimmune disease, cardiovascular disease, cancer, liver cirrhosis, and ischemic stroke. On the other hand, studies have shown that paracrine factors, not direct cell replacement for damaged cells or tissue, are the main contributors in MSC-based therapy. More recently, evidence has indicated that MSC-derived exosomes play crucial roles in regulating the paracrine factors that can mediate tissue regeneration via transferring nucleic acids, proteins, and lipids to the local microenvironment and cell-to-cell communication. The use of these exosomes is likely to be beneficial for the therapeutic application of MSCs because their use can avoid harmful effects, such as tumor formation involved in cell transplantation. Therefore, therapeutic applications using MSC-derived exosomes might be safe and efficient strategies for regenerative medicine and tissue engineering. This review summarizes the recent advances and provides a comprehensive understanding of the role of MSC-derived exosomes as a therapeutic agent.
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참고문헌 (52)
참고문헌 신청
허준석 / 2015 / Chondrogenic Differentiation of Human Mesenchymal Stem Cells on a Patterned Polymer Surface / 대한임상검사과학회지 47(3):117~124
Wang LT / 2016 / Human mesenchymal stem cells(MSCs)for treatment towards immune-and inflammation-mediated diseases : review of current clinical trials / J Biomed Sci 23:76
Lee PH / 2012 / A randomized trial of mesenchymal stem cells in multiple system atrophy / Ann Neurol 72:32~40
Hodgkinson CP / 2016 / Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology / Circ Res 118:95~107
Toma C / 2009 / Fate of culture-expanded mesenchymal stem cells in the microvasculature : in vivo observations of cell kinetics / Circ Res 104:398~402
Wang LT / 2016 / Human mesenchymal stem cells(MSCs)for treatment towards immune-and inflammation-mediated diseases : review of current clinical trials / J Biomed Sci 23:76
Lee PH / 2012 / A randomized trial of mesenchymal stem cells in multiple system atrophy / Ann Neurol 72:32~40
Hodgkinson CP / 2016 / Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology / Circ Res 118:95~107
Toma C / 2009 / Fate of culture-expanded mesenchymal stem cells in the microvasculature : in vivo observations of cell kinetics / Circ Res 104:398~402
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