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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 117 - 124 (8page)
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초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) are an attractive tool in tissue engineering as they have the required potential to treat injured articular cartilage. UV-exposed DTOPV (S-triazine bridged p-phenylene vinylene) is a biocompatible and fluorescent polymer with a hydrophilic surface. Previous studies have demonstrated that the surface wettability and hydrophilicity play critical roles in regulating cell adhesion and proliferation. The objective of this study was to improve the potential of in vitro MSC differentiation into Chondrocytes using DTOPV. MSCs were cultured on two different substrates: (1) tissue culture polystyrene (TCPS) as a reference and (2) UV-exposed and patterned DTOPV films. Chondrogenesis of MSCs was induced for two weeks on TCPS and DTOPV in the presence of an induction medium containing transforming growth factor (TGF)-3. Interestingly, the MSCs on TCPS adhered and spread, while those on DTOPV tended to form aggregates within several days. The cells cultured on DTOPV for two weeks had a round morphology, with stronger Safranine O staining of the extracellular matrix than that of the cells cultured on TCPS. Also, Type II collagen gene was significantly expressed in cells induced on DTOPV. These results indicate that chondrogenic differentiation of MSCs proceeds more rapidly on DTOPV than on TCPS. Therefore, in cartilage tissue engineering, DTOPV could be used to induce effective chondrogenic differentiation of MSCs.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Caplan Al / 1994 / The mesengenic process / Clin Plast Surg 21 : 429 ~ 435
Cho H / 2002 / Highly fluorescent and photochromic diarylethene oligomer bridged by p-phenylenevinylene / Macromolecules 35 : 8684 ~ 8687
Djouad F / 2006 / Engineered mesenchymal stem cells for cartilage repair / Regen Med 1 : 529 ~ 537
Friedenstein AJ / 1966 / Osteogenesis in transplants of bone marrow cells / J Embryol Exp Morphol 16 : 381 ~ 390
Jiang Y / 2002 / Pluripotency of mesenchymal stem cells derived from adult marrow / Nature 418 : 41 ~ 49
Cho H / 2002 / Highly fluorescent and photochromic diarylethene oligomer bridged by p-phenylenevinylene / Macromolecules 35 : 8684 ~ 8687
Djouad F / 2006 / Engineered mesenchymal stem cells for cartilage repair / Regen Med 1 : 529 ~ 537
Friedenstein AJ / 1966 / Osteogenesis in transplants of bone marrow cells / J Embryol Exp Morphol 16 : 381 ~ 390
Jiang Y / 2002 / Pluripotency of mesenchymal stem cells derived from adult marrow / Nature 418 : 41 ~ 49
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