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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 69 - 78 (10page)
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Cordyceps militaris has been used in traditional Chinese medicine owing to its anticancer and immunomodulatory activities. Germanium compounds have also been shown to be associated with many pharmacological functions, such as antimicrobial, antiviral, antitumor, antimutagenic, and immunomodulating effects. In this study, we examined the biological properties of hot water extract from mycelial liquid culture of germanium-enriched C. militaris (CMGe). CMGe displayed a concentration-dependent antiproliferation activity against four human cancer cell lines. The antiproliferative activity of CMGe was 2−4-fold lower than that of hot water extract from mycelial liquid culture in C. militaris (CM). However, CM had a concentration-dependent cytotoxicity to human bone marrow-derived mesenchymal stem cells (MSCs). Contrastingly, CMGe did not cause any cellular damage to MSCs. MSCs cultured with CMGe displayed an increased proliferative activity with no cytotoxic effect. The oral administration of CMGe inhibited increased tumor volume and weight compared with the control group. CMGe has the potential to be used as an industrial product in medicinal foods as well as in pharmaceutical products.
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참고문헌 (26)
참고문헌 신청
Dong JZ / 2012 / Selenium enrichment on Cordyceps militaris link and analysis on its main active components / Appl Biochem Biotechnol 166(5):1215~1224
Shang D / 2011 / A novel polysaccharide from Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells / Oncol Rep 25(1):267~272
Aso H / 1985 / Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, an organic germanium compound / Microbiol Immunol
Aso H / 1989 / Antiviral activity of carboxyethylgermanium sesquioxide (Ge-132) in mice infected with influenza virus / J Biol Response Mod 8 (2) : 180 ~ 189
Brutkiewicz RR / 1987 / Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132 (review) / In Vivo 1 (4) : 189 ~ 203
Shang D / 2011 / A novel polysaccharide from Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells / Oncol Rep 25(1):267~272
Aso H / 1985 / Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, an organic germanium compound / Microbiol Immunol
Aso H / 1989 / Antiviral activity of carboxyethylgermanium sesquioxide (Ge-132) in mice infected with influenza virus / J Biol Response Mod 8 (2) : 180 ~ 189
Brutkiewicz RR / 1987 / Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132 (review) / In Vivo 1 (4) : 189 ~ 203
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