Prognostic Significance of Serine-Phosphorylated STAT3 Expression in pT1–T2 Oral Tongue Carcinoma

Luciano Giacomelli; Cosimo de Filippis; Rocco Cappellesso; Filippo Marino; Alberto Staffieri; Gino Marioni; Claudia Staffieri; Giancarlo Ottaviano; Matteo Val; Edoardo Stellini; Elena Fasanaro

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자료유형: 학술저널

저자정보: Luciano Giacomelli Cosimo de Filippis Rocco Cappellesso Filippo Marino Alberto Staffieri Gino Marioni Claudia Staffieri Giancarlo Ottaviano Matteo Val Edoardo Stellini Elena Fasanaro

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제8권 제3호

발행연도: 2015.1

수록면: 275 - 280 (6page)

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Objectives. Phosphorylated (activated) STAT3 (pSTAT3) is a regulator of numerous genes that play an essential part in the onset, development and progression of cancer; it is involved in cell proliferation and preventing apoptosis, and in invasion, angiogenesis, and the evasion of immune surveillance. This study aimed mainly to investigate the potential prognostic role of pSTAT3 expression in oral tongue squamous cell carcinoma (SCC). Methods. Phospho-ser727 STAT3 immunolabeling was correlated with prognostic parameters in 34 consecutive cases of pT1–T2 tongue SCCs undergoing primary surgery. Computer-based image analysis was used for the immunohistochemical reactions analysis. Results. Statistical analysis showed a difference in disease-free survival (DFS) when patients were stratified by pN status (P=0.031). Most tumors had variable degrees (mean±SD, 80.7%±23.8%) of intense nuclear immunoreaction to pSTAT3. Our findings rule out any significant association of serine-phosphorylated nuclear STAT3 expression with tumor stage, grade, lymph node metastasis, recurrence rate, or DFS. Conclusion. In spite of these results, it is worth further investigating the role of pSTAT3 (serine- and tyrosine-pSTAT3) in oral tongue SCC in larger series because preclinical models are increasingly showing that several anticancer strategies would benefit from STAT3 phosphorylation inhibition.

#Tongue Neoplasms #STAT3 Transcription Factor #Lymph Nodes #Prognosis

참고문헌 (22)

참고문헌 신청

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Grandis JR / 1993 / Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and ne

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