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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 217 - 220 (4page)
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초록· 키워드
오류제보하기
To monitor cell trafficking in vivo and distinguish whether cellular regeneration originated from an exogenous cell source is a key issue for developing successful stem cell therapies, nanoparticles are increasingly used in different applications, including bioimaging, diagnostic technology, and drug/gene delivery. Thus, it is important to develop methods using nanoparticles that can monitor the fate and distribution of transplanted stem cells noninvasively for further applications. In our system, nano fluorescent particle uptake bone marrow derived-mesenchymal stem cells (BM-MSC) not neural stem cells at an incubation dosage 0.1 ㎎/mL of culture medium. Furthermore, nano fluorescent particle labeled BMMSC can also be detected in a neurodegenerative mouse model in vivo. Our results are the first report that BM-MSCs can be efficiently labeled with nanoparticles and can be monitored in vitro and in vivo.
목차
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (19)
참고문헌 신청
Bae, J.S , 2005 , Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice , Hum. Gene Ther 16 : 1006 ~ 1011
Christoforou, N , 2007 , Stem cells and their potential in cell-based cardiac therapies , Prog. Cardiovasc. Dis 49 : 396 ~ 413
Jin, H.K , 2002 , Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span , J. Clin. Invest 109 : 1183 ~ 1191
Jin, H.K , 2003 , Ex vivo gene therapy using bone marrow-derived cells: combined effects of intracerebral and intravenous transplantation in a mouse model of Niemann-Pick disease , Mol. Therapy 8 : 876 ~ 885
Lee, R.H , 2006 , Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic pancreatic islets and renal glomeruli in diabetic NOD, scid mice , Proc. Natl. Acad. Sci. USA 103 : 17438 ~ 17443
Christoforou, N , 2007 , Stem cells and their potential in cell-based cardiac therapies , Prog. Cardiovasc. Dis 49 : 396 ~ 413
Jin, H.K , 2002 , Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span , J. Clin. Invest 109 : 1183 ~ 1191
Jin, H.K , 2003 , Ex vivo gene therapy using bone marrow-derived cells: combined effects of intracerebral and intravenous transplantation in a mouse model of Niemann-Pick disease , Mol. Therapy 8 : 876 ~ 885
Lee, R.H , 2006 , Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic pancreatic islets and renal glomeruli in diabetic NOD, scid mice , Proc. Natl. Acad. Sci. USA 103 : 17438 ~ 17443
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UCI(KEPA) : I410-ECN-0101-2009-510-014844042