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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 815 - 821 (7page)
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초록· 키워드
오류제보하기
Olfactory dysfunction is one of the most debilitating problem in chronic rhinosinusitis (CRS) patients, and exact mechanism underlying sinusitis induced olfactory dysfunction was not fully understood. In vivo manipulation for olfactory epithelium and fresh specimen for histopathological analysis are essential for research, but it is nearly impossible to do in human due to inaccessibility of olfactory epithelium and risk for complication. For this reason, several animal models using toxic materials, such as 3-methylindole or bromomethane, have been suggested for mimicking olfactory epithelial damage in CRS, but none of them could truly imitate the event which happens in real patient. Inducible olfactory inflammation (IOI) mouse is a transgenic mouse model selectively producing tumor necrosis factor-alpha (TNF-α) in sustentacular cell of olfactory epithelium. The production of TNF-α can be actively initiated by giving food containing doxycycline to IOI mouse, and inflammation is stopped in the absence of doxycycline. Both toxicity model and transgenic model have their own advantages and disadvantages, therefore appropriate model should be selected for optimal results.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Miller MA / 2003 / 3-methylindole induces transient olfactory mucosal injury in ponies / Vet Pathol 40(4):363~370
Kim HY / 2012 / Effects of statins on the recovery of olfactory function in a 3-methylindole-induced anosmia mouse model / Am J Rhinol Allergy 26(2):e81~e84
Kim JW / 2010 / Relationship between olfactory function and olfactory neuronal population in C57BL6mice injected intraperitoneally with 3-methylindole / Otolaryngol Head Neck Surg 143(6):837~842
Miller MA / 2003 / Ultrastructural changes and olfactory deficits during 3-methylindole-induced olfactory mucosal necrosis and repair in mice / Ultrastruct Pathol 27(1):13~21
Kern RC / 2004 / Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction / Laryngoscope 114(2):279~285
Kim HY / 2012 / Effects of statins on the recovery of olfactory function in a 3-methylindole-induced anosmia mouse model / Am J Rhinol Allergy 26(2):e81~e84
Kim JW / 2010 / Relationship between olfactory function and olfactory neuronal population in C57BL6mice injected intraperitoneally with 3-methylindole / Otolaryngol Head Neck Surg 143(6):837~842
Miller MA / 2003 / Ultrastructural changes and olfactory deficits during 3-methylindole-induced olfactory mucosal necrosis and repair in mice / Ultrastruct Pathol 27(1):13~21
Kern RC / 2004 / Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction / Laryngoscope 114(2):279~285
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