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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 637 - 643 (7page)
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초록· 키워드
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Radioimmunotherapy (RIT) is a therapy that takes advantage of the “cross-fire” effect ofemitted radiation by radionuclides conjugated to tumor-directed monoclonal antibodies (mAb)(including those fragments) or peptides. While RIT has been successfully employed for thetreatment of lymphoma, mostly with radiolabeled antibodies against CD20 [90yttrium (90Y)-ibritumomab tiuxetan; Zevalin® and 131iodine (131I)-tositumomab; Bexxar®], its use in solid tumorsis more challenging, so far. Immuno-PET, a tool for tracking and quantification of mAbswith PET in vivo, is an exciting novel option to improve diagnostic imaging and guide mAbbasedtherapy. RIT in solid tumors including head and neck cancer may be an alternative treatmentwith advances in various biological, chemical, and treatment procedures, and it may helpto reduce unnecessary exposure and enhance the therapeutic efficacy. Also, immuno-PET basedon RIT might play an important role in cancer staging, in patients or targets selection of targetedtherapeutics and in monitoring the response of targeted therapeutics as precision medicine. In this review, fundamentals of RIT/immune-PET and current knowledge of the preclinical/clinical trials in RIT for solid tumor including head and neck cancer are reviewed.
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참고문헌 (42)
참고문헌 신청
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Dassonville O / 1993 / Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer / J Clin Oncol 11(10):1873~1878
Rubin Grandis J / 1998 / Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival / J Natl Cancer Inst 90(11):824~832
Soulieres D / 2004 / Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck / J Clin Oncol 22(1):77~85
Vermorken JB / 2007 / Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy / J Clin Oncol 25(16):2171~2177
Dassonville O / 1993 / Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer / J Clin Oncol 11(10):1873~1878
Rubin Grandis J / 1998 / Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival / J Natl Cancer Inst 90(11):824~832
Soulieres D / 2004 / Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck / J Clin Oncol 22(1):77~85
Vermorken JB / 2007 / Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy / J Clin Oncol 25(16):2171~2177
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