지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 73 - 80 (8page)
이용수
초록· 키워드
오류제보하기
The lungs are highly defensive to environmental challenges thanks to the airway mucus layer, not only as a pool of antimicrobial and antioxidant contents but also as an important part of physical barrier and mucociliary clearance. This review comprises the mechanism of airway mucus production; synthesis, exocytosis to the airway lumen and dilution of gel-forming mucins. Airway mucus consists of mainly water and mucins, highly glycosylated and condensed proteins. The mucins are produced in the mucin-secreting cells, in which interleukin-13 is one of the synthesis stimulators. Mucins are processed and maturated in the cytoplasm, and then released into the airway in two ways, constitutive and regulated. The constitutive exocytosis might be essential in maintaining normal airway mucus gel layer. The regulated exocytosis occurs mainly in the diseased airway, agonized by ATP through P2Y2 purinergic receptors. Secreted mucins are immediately hydrated through the osmotic pressure on the airway epithelium. Water and bicarbonate contents in the lumen are important factors determining the physical properties, especially the viscosity of the airway mucus.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Ali M / 2011 / Analysis of the proteome of human airway epithelial secretions / Proteome Sci 9 : 4 ~
Behrendorff N / 2011 / Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required
Blank U / 2011 / The mechanisms of exocytosis in mast cells / Adv Exp Med Biol 716 : 107 ~ 122
Brunger AT / 2005 / Structure and function of SNARE and SNARE-interacting proteins / Q Rev Biophys 38 : 1 ~ 47
Chen EY / 2010 / A new role for bicarbonate in mucus formation / Am J Physiol Lung Cell Mol Physiol 299 : L542 ~ L549
Behrendorff N / 2011 / Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required
Blank U / 2011 / The mechanisms of exocytosis in mast cells / Adv Exp Med Biol 716 : 107 ~ 122
Brunger AT / 2005 / Structure and function of SNARE and SNARE-interacting proteins / Q Rev Biophys 38 : 1 ~ 47
Chen EY / 2010 / A new role for bicarbonate in mucus formation / Am J Physiol Lung Cell Mol Physiol 299 : L542 ~ L549
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