아세틸콜린이 외유모세포 칼륨 전류 및 길이 변화에 미치는 영향

조형호; 이준규; 이재홍; 장명주; 황매; 정한성; 조용범; 박종성

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자료유형: 학술저널

저자정보: 조형호 이준규 이재홍 장명주 황매 정한성 조용범 박종성

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제2호

발행연도: 2005.1

수록면: 153 - 157 (5page)

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Background and Objectives：Iner hair cells (IHCs) of the organ of Corti change the external sound stimulus into the elect-rical signal and transmit this signal to the auditory cortex through afferent nerve fibers. Outer hair cels (OHCs) control the sound transmission function of IHC. OHCs respond with a somatic shape change to alterations in their membrane potential and this electromotile response is believed to provide mechanical fedback to the basilar membrane. Eferent nerve fibers which arise from the superior olivary nucleus in the midbrain and transmit to OHCs through medial olivocochlear bundle use acetylcholine (ACh) as a neurotransmiter. The cholinergic response of OHCs α-9 nicotinic ACh receptor increase the Ca2+ influx, which control OHCs electromotility by changing a membrane potential. In this research, the effect of ACh on the K+ current in OHC of guinea pig was studied, and the change of OHC length by ACh was studied. Materials and Methods：Using the extracted change of OHC length when ACh was applied was observed. Results：1) ACh increases voltage-dependent K+ current in OHC. 2) In the condition, which Ca2+-dependent K+ current is blocked by removing Ca2+ from intra-cellular fluid, ACh has no effect on K+ current in OHC. 3) ACh increases OHC length. Conclusion：These experimental results show that ACh from the medial olivocochlear eferent system regulates mobility of OHC, increases the Ca2+-dependent K+ currents in OHC.

#외유모세포·칼슘의존성 칼륨 채널·아세틸콜린. #Outer hair cell· Potassium channels· Calcium· Acetylcholine.

참고문헌 (11)

참고문헌 신청

/ / An acetylcholine receptor with novel pharmacological propertiesexpressed in rat cochlear hair cells : 705 ~ 15

/ / Improvedpatch-clamp techniques for high-resolution current recording fromcells and cell-free membrane patches : 85 ~ 100

/ 1995 / Cell-specific expression of the alpha 9 n-ACh receptor subunitin auditory hair cells revealed by single-cell RT-PCR : 141 ~ 7

/ 1997 / Expression of the nicotinicacetylcholine receptor subunit : 95 ~ 105

/ 1997;17 / Acetylcholine, : 2212 ~ 26

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