고농도의 칼륨이온자극과 세포내 칼슘이온증가에 의해 유발되는 외유모세포의 길이 변화에 미치는 아세틸콜린의 영향

조용건; 안중호; 정종우; 이광선; 이석우

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자료유형: 학술저널

저자정보: 조용건 안중호 정종우 이광선 이석우

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제45권 제7호

발행연도: 2002.1

수록면: 641 - 645 (5page)

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Background and Objectives：It has been known that the motility of the outer hair cell controls the physiological charact-eristics of the organ of Corti. Motility can be divided into two different types；fast and slow motility. Slow motility can be induced by high concentration of KCl and increase of intracellular Ca2+ concentration. In this study, authors aimed to define the efect of acetylcholine, one of the eferent neurotransmitters, on the slow motility of the outer hair cells of guinea pig. Materials and Method：length of the hair cells was recorded by CCD camera equipped on an inverted microscope. Slow motility was induced by 10 μM of ionomycin and 150 mM of KCl. Carbamylcholine (1 mM), a non-hydrolyzable derivative of acetylcholine, was used to observe the effect of acetylcholine and choline chloride (1 mM) was used as control. Results：The length of outer hair cell was decreased after adding 150 mM of KCl and increased after adding 10 μM of ionomycin. Stimulation of carbamylch-oline (1 mM)afect the length change induced by ionomycin or KCl in outer hair cells. Conclusion：We could sugest that carbamylch-oline does not have an effect on the slow motility of outer hair cell induced by the change of osmotic pressure which was elicited by high potassium, or intracellular Ca2+ increase. (Korean J Otolaryngol 2002;45:641-5)

#외유모세포·칼슘·아세틸콜린·염화칼륨·원심성신경. #Outer hair cells· Calcium· Acetylcholine· Potassium chloride· Efferent neurons.

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