만성 타액선염에서 Cathelicidin의 발현

이흥만; 정승원; 황순재; 우정수; 정지용

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자료유형: 학술저널

저자정보: 이흥만 정승원 황순재 우정수 정지용

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제2호

발행연도: 2005.1

수록면: 204 - 207 (4page)

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Background and Objectives：Salivary secretions and the secreted IgA in the secretions play a critical role in maintaining oral health via innate host defense mechanism. Cathelicidins are a family of peptides thought to provide an innate defensive barrier against a variety of potential microbial pathogens. LL-37, an antimicrobial peptide, is the only Cathelicidin protein so far identified in humans. The purpose of this study was to examine the expression of Cathelicidin in human salivary glands and to investigate upregulation of Cathelicidin in inflammatory conditions. Materials and Method：Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemical staining were performed on 20 salivary gland tissues, of which 10 were normal and 10 were chronic sialadenitis. Results：Cathelicidin mRNA transcripts were detected in the normal salivary glands and chronic sialadenitis. The level of Cathelicidin mRNA in chronic sialadenitis was significantly increased compared with that in the normal salivary gland. Cathelicidin protein was expressed in the glandular epithelium of the normal salivary gland and chronic sialadenitis. Conclusion：The results indicate that Cathelicidin might play an important role in the innate host defense of human salivary glands.

#Cathelicidin·역전사 중합효소반응·면역조직화학적 염색·타액선염. #Cathelicidin· Reverse transcriptase-polymerase chain reaction #RT-PCR)· Imunohistochemical staining·Sialadenitis.

참고문헌 (18)

참고문헌 신청

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