만성 타액선염에서 표면활성제 단백-A의 상향조절

박일호; 우정수; 이정규; 임현우; 황순재; 이흥만

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자료유형: 학술저널

저자정보: 박일호 우정수 이정규 임현우 황순재 이흥만

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제4호

발행연도: 2006.1

수록면: 411 - 414 (4page)

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연구배경

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연구방법

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Background and Objectives：Surfactant protein-A (SP-A) is a member of the collectin family, and plays an important role in the first-line airway defense. The purpose of study was to examine the expression of SP-A mRNA and protein in human salivary glands, and to investigate its up-regulation during inflammatory conditions of salivary glands. Materials and Method：Reverse transcription-polymerase chain reaction was performed on salivary gland tissues from ten patients with chronic sialadenitis and ten samples of normal salivary gland tissue. The expression levels of SP-A to GAPDH (glyceraldehyde-3-phosphate dehydrogenase) transcripts were semi-quantified by densitometry. We also characterized the cellular localizations of SP-A protein immunohistochemically. Results：SP-A mRNA and protein were detected in normal and chronic sialadenitis glands. The expression levels of SP-A mRNA in salivary glands with chronic sialadenitis was significantly increased as compared with normal salivary glands. Immunohistochemical staining revealed SP-A immunoreactivity in the ductal epithelia of normal salivary glands and chronic sialadenitis, and stronger immunoreactivity was observed in chronic sialadenitis tissues. Conclusion：SP-A is present in the human salivary gland epithelium and is up-regulated during chronic sialadenitis. These results suggest that salivary gland SP-A may play an important role in the innate host defense of human salivary glands. (Korean J Otolaryngol 2006; 49:411-4)

#표면활성제 단백 A·타액선염. #Surfactant protein A·Sialadenitis.

참고문헌 (20)

참고문헌 신청

/ 1995 / Interactions of pulmonary surfactant protein A withinfluenza A viruses:Binding and neutralization 171 : 335 ~ 341

/ 1995 / Pulmonary surfactant protein A(SP-A) is expressed byepithelial cells of small and large intestine 270 : 12162 ~ 12169

/ 1995 / Surfactant protein a promotes attachment of Mycobacterium tuberculosisto alveolar macrophages during infection with human immunodeficiencyvirus 92 : 4848 ~ 4852

/ 1996 / Overexpression of surfactant protein SP-A and SP-C mRNA inrat lungs with lipopolysaccharide-induced injury 74 : 209 ~ 220

/ 1996 / Surfactant content in children with inflammatory lung disease 24 : 1062 ~ 1067

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