지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.4
- 수록면
- 1 - 26 (26page)
이용수
초록· 키워드
오류제보하기
Vitamin D signaling plays an essential role in innate defense against intracellular microorganisms via the generation of the antimicrobial protein cathelicidin. In addition to directly binding to and killing a range of pathogens, cathelicidin acts as a secondary messenger driving vitamin D-mediated inflammation during infection. Recent studies have elucidated the biological and clinical functions of cathelicidin in the context of vitamin D signaling. The vitamin D-cathelicidin axis is involved in the activation of autophagy, which enhances antimicrobial effects against diverse pathogens. Vitamin D studies have also revealed positive and negative regulatory effects of cathelicidin on inflammatory responses to pathogenic stimuli. Diverse innate and adaptive immune signals crosstalk with functional vitamin D receptor signals to enhance the role of cathelicidin action in cell-autonomous effector systems. In this review, we discuss recent findings that demonstrate how the vitamin D-cathelicidin pathway regulates autophagy machinery, protective immune defenses, and inflammation, and contributes to immune cooperation between innate and adaptive immunity. Understanding how the vitamin D-cathelicidin axis operates in the host response to infection will create opportunities for the development of new therapeutic approaches against a variety of infectious diseases.
목차
ABSTRACT
INTRODUCTION
OVERVIEW OF VITAMIN D METABOLISM AND SIGNALING
CATHELICIDINS AND VITAMIN D-INDUCED ANTIMICROBIAL RESPONSES
THE VITAMIN D-CATHELICIDIN AXIS AND AUTOPHAGY REGULATION
VITAMIN D-CATHELICIDIN SIGNALING IN THE REGULATION OF INFLAMMATION
CLINICAL TRIALS OF VITAMIN D-CATHELICIDIN AXIS IN INFECTIOUS DISEASES
CONCLUSION
REFERENCES
참고문헌 (132)
참고문헌 신청
Watkins RR / 2015 / An update on the association of vitamin D deficiency with common infectious diseases / Can J Physiol Pharmacol 93:363~368
Korf H / 2014 / Vitamin D for infections / Curr Opin Endocrinol Diabetes Obes 21:431~436
신동민 / 2011 / Antimicrobial Peptides in Innate Immunity against Mycobacteria / Immune Network 11(5):245~252
Afacan NJ / 2012 / Therapeutic potential of host defense peptides in antibiotic-resistant infections / Curr Pharm Des 18:807~819
Hasan M / 2019 / Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes-single giant unilamellar vesicle studies / Adv Exp Med Biol 1117:17~32
Korf H / 2014 / Vitamin D for infections / Curr Opin Endocrinol Diabetes Obes 21:431~436
신동민 / 2011 / Antimicrobial Peptides in Innate Immunity against Mycobacteria / Immune Network 11(5):245~252
Afacan NJ / 2012 / Therapeutic potential of host defense peptides in antibiotic-resistant infections / Curr Pharm Des 18:807~819
Hasan M / 2019 / Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes-single giant unilamellar vesicle studies / Adv Exp Med Biol 1117:17~32
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Study on Vitamin D and Cathelicidin Status in Patients with Rosacea: Serum Level and Tissue Expression
Annals of Dermatology
2018 .01
-
Should We Measure Vitamin D Level?
Acute and Critical Care
2016 .01
-
Vitamin D in COVID - 19: Dousing the fire or averting the storm? e A perspective from the Asia-Pacific
Osteoporosis and Sarcopenia
2020 .01
-
The Specific Roles of Vitamins in the Regulation of Immunosurveillance and Maintenance of Immunologic Homeostasis in the Gut
Immune Network
2017 .02
-
Vitamin D and COVID-19: Is something better than nothing?
Osteoporosis and Sarcopenia
2020 .01
-
소아 아토피피부염에서 비타민 D의 역할
Allergy Asthma & Respiratory Diseases
2015 .01
-
Vitamin D Levels in Patients with Low-energy Hip Fractures
Hip and Pelvis
2020 .01
-
Vitamin D and Hypertension
Electrolytes & Blood Pressure
2017 .01
-
Vitamin D insufficiency and its contributing factors in primary school-aged children in Indonesia, a sun-rich country
Annals of Pediatirc Endocrinology & Metabolism
2021 .01
-
Vitamin D and the Immune System in Menopause: A Review
대한폐경학회지
2021 .12
-
The effect of metformin on vitamin B12 level in pediatric patients
Annals of Pediatirc Endocrinology & Metabolism
2022 .09
-
Vitamin C as a Possible Therapy for COVID-19
Infection and Chemotherapy
2020 .01
-
Vitamin C Deficiency of Korean Homeless Patients Visiting to Emergency Department with Acute Alcohol Intoxication
Journal of Korean Medical Science
2015 .01
-
Mechanistic Effects of Vitamin D Supplementation on Metabolic Syndrome Components in Patients with or without Vitamin D Deficiency
Journal of Obesity & Metabolic Syndrome
2020 .01
-
Gestational Diabetes Mellitus, Fetal Growth and Vitamin D
대한골대사학회지
2017 .08
-
Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features
Clinical and Experimental Pediatrics
2015 .01
-
The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea
대한직업환경의학회지
2017 .07
-
Practical Vitamin D Supplementation Using Machine Learning
대한골대사학회지
2020 .01
-
국내 운동선수에서 비타민 D 수치의 현 상태 및 결핍과 관련된 인자: 실내외 종목에 따른 차이, 나이, 성별, 체질량지수, 계절 변동과의 관련성
대한스포츠의학회지
2018 .01
-
The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women
대한골대사학회지
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-517-000894475